FMRP stalls ribosomal translocation on mRNAs linked to synaptic function and autism
Jennifer C. Darnell,Sarah J. Van Driesche,Chaolin Zhang,Ka Ying Sharon Hung,Aldo Mele,Claire E. Fraser,Elizabeth F. Stone,Cynthia Chen,John J. Fak,Sung Wook Chi,Donny D. Licatalosi,Joel D. Richter,Robert B. Darnell,Robert B. Darnell +13 more
TLDR
A brain polyribosome-programmed translation system is developed, revealing that FMRP reversibly stalls ribosomes specifically on its target mRNAs and suggests multiple targets for clinical intervention in FXS and ASD.About:
This article is published in Cell.The article was published on 2011-07-22 and is currently open access. It has received 1861 citations till now. The article focuses on the topics: FMR1 & RNA-binding protein.read more
Citations
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Journal ArticleDOI
Replication Stress Induces Global Chromosome Breakage in the Fragile X Genome.
Arijita Chakraborty,Piroon Jenjaroenpun,Jing Li,Sami El Hilali,Sami El Hilali,Andrew McCulley,Brian Haarer,Elizabeth Hoffman,Aimee Belak,Audrey Thorland,Heidi Hehnly,Carl L. Schildkraut,Chun-Long Chen,Chun-Long Chen,Vladimir A. Kuznetsov,Vladimir A. Kuznetsov,Wenyi Feng +16 more
TL;DR: The results suggest that FMRP is a genome maintenance protein that prevents R-loop accumulation and provides insights into the etiological basis for FXS.
Journal ArticleDOI
Integrative Analysis of Brain Region-specific Shank3 Interactomes for Understanding the Heterogeneity of Neuronal Pathophysiology Related to SHANK3 Mutations.
Yeunkum Lee,Hyojin Kang,Bokyoung Lee,Yinhua Zhang,Yoonhee Kim,Shinhyun Kim,Won Ki Kim,Kihoon Han +7 more
TL;DR: This study investigated whether Shank3 could form protein complexes in a brain region-specific manner, which might contribute to the heterogeneity of neuronal pathophysiology caused by SHANK3 mutations, and suggested that the mPFC- and HP+STR-specific Shank3 interactomes contained a significant number of proteins associated with neurodevelopmental and neuropsychiatric disorders.
Journal ArticleDOI
Impaired motor skill learning and altered seizure susceptibility in mice with loss or gain of function of the Kcnt1 gene encoding Slack (K Na 1.1) Na + -activated K + channels
Imran H. Quraishi,Michael R. Mercier,Heather McClure,Rachael Couture,Michael L. Schwartz,Robert Lukowski,Peter Ruth,Leonard K. Kaczmarek +7 more
TL;DR: It is suggested that Slack channels are required for the development of procedural learning and of pathways that link cortical seizures to other regions required for animal survival.
Journal ArticleDOI
Roles of the HUWE1 ubiquitin ligase in nervous system development, function and disease.
Andrew C. Giles,Brock Grill +1 more
TL;DR: This work discusses extensive progress made in deciphering how Huwe1 regulates neural progenitor proliferation and differentiation, cell migration, and axon development, and highlights recent evidence indicating that Huwe 1 regulates inhibitory neurotransmission.
Book ChapterDOI
Post-Translational Modifications and RNA-Binding Proteins.
TL;DR: This chapter summarizes the work that has been done to identify the consequence of post-translational modifications to some RNA-binding proteins and the effects of these modifications have been shown to increase the panoply of functions that a givenRNA-binding protein can assume.
References
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Biometry: The Principles and Practice of Statistics in Biological Research
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TL;DR: In this paper, the authors present a model for the analysis of variance in a single-classification and two-way and multiway analysis of Variance with the assumption of correlation.
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