FMRP stalls ribosomal translocation on mRNAs linked to synaptic function and autism
Jennifer C. Darnell,Sarah J. Van Driesche,Chaolin Zhang,Ka Ying Sharon Hung,Aldo Mele,Claire E. Fraser,Elizabeth F. Stone,Cynthia Chen,John J. Fak,Sung Wook Chi,Donny D. Licatalosi,Joel D. Richter,Robert B. Darnell,Robert B. Darnell +13 more
TLDR
A brain polyribosome-programmed translation system is developed, revealing that FMRP reversibly stalls ribosomes specifically on its target mRNAs and suggests multiple targets for clinical intervention in FXS and ASD.About:
This article is published in Cell.The article was published on 2011-07-22 and is currently open access. It has received 1861 citations till now. The article focuses on the topics: FMR1 & RNA-binding protein.read more
Citations
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Evaluating historical candidate genes for schizophrenia.
Martilias S. Farrell,Thomas Werge,Pamela Sklar,Michael John Owen,Roel A. Ophoff,Michael Conlon O'Donovan,Aiden Corvin,Sven Cichon,Patrick F. Sullivan +8 more
TL;DR: The historical candidate gene literature did not yield clear insights into the genetic basis of schizophrenia, and the considerable efforts embodied in these early studies unquestionably set the stage for current successes in genomic approaches to schizophrenia.
Journal ArticleDOI
Genetic Removal of p70 S6 Kinase 1 Corrects Molecular, Synaptic, and Behavioral Phenotypes in Fragile X Syndrome Mice
Aditi Bhattacharya,Hanoch Kaphzan,Amanda C. Alvarez-Dieppa,Jaclyn P. Murphy,Philippe Pierre,Philippe Pierre,Eric Klann +6 more
TL;DR: The model that dysregulated protein synthesis is the key causal factor in Fragile X syndrome and that restoration of normal translation can stabilize peripheral and neurological function in FXS is supported.
Journal ArticleDOI
Remote Control of Gene Function by Local Translation
TL;DR: Key findings in this area are discussed and possible implications of this adaptable and swift mechanism for spatial control of gene function are discussed.
Journal ArticleDOI
Local protein synthesis is a ubiquitous feature of neuronal pre- and postsynaptic compartments
Anne-Sophie Hafner,Paul G. Donlin-Asp,Beulah Leitch,Etienne Herzog,Etienne Herzog,Erin M. Schuman +5 more
TL;DR: In the absence of overt stimulation, there was a notably high level of ongoing protein synthesis in both pre- and postsynaptic compartments, including excitatory and inhibitory axon terminals.
Journal ArticleDOI
Prospective investigation of autism and genotype-phenotype correlations in 22q13 deletion syndrome and SHANK3 deficiency.
Latha Soorya,Latha Soorya,Alexander Kolevzon,Jessica Zweifach,Teresa Lim,Yuriy Dobry,Lily Schwartz,Yitzchak Frank,A. Ting Wang,Guiqing Cai,Elena Parkhomenko,Danielle Halpern,David Grodberg,Benjamin Angarita,Judith P. Willner,Amy Yang,Roberto Canitano,William F. Chaplin,Catalina Betancur,Catalina Betancur,Catalina Betancur,Joseph D. Buxbaum +21 more
TL;DR: Findings from previous research on the severity of intellectual, motor, and speech impairments seen in SHANK3 deficiency are supported, and highlights the prominence of autism spectrum disorder in the syndrome.
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