FMRP stalls ribosomal translocation on mRNAs linked to synaptic function and autism
Jennifer C. Darnell,Sarah J. Van Driesche,Chaolin Zhang,Ka Ying Sharon Hung,Aldo Mele,Claire E. Fraser,Elizabeth F. Stone,Cynthia Chen,John J. Fak,Sung Wook Chi,Donny D. Licatalosi,Joel D. Richter,Robert B. Darnell,Robert B. Darnell +13 more
TLDR
A brain polyribosome-programmed translation system is developed, revealing that FMRP reversibly stalls ribosomes specifically on its target mRNAs and suggests multiple targets for clinical intervention in FXS and ASD.About:
This article is published in Cell.The article was published on 2011-07-22 and is currently open access. It has received 1861 citations till now. The article focuses on the topics: FMR1 & RNA-binding protein.read more
Citations
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Novel RNA- and FMRP-binding protein TRF2-S regulates axonal mRNA transport and presynaptic plasticity.
Peisu Zhang,Kotb Abdelmohsen,Yong Liu,Kumiko Tominaga-Yamanaka,Je-Hyun Yoon,Grammatikakis Ioannis,Jennifer L. Martindale,Yongqing Zhang,Kevin G. Becker,In Hong Yang,Myriam Gorospe,Mark P. Mattson,Mark P. Mattson +12 more
TL;DR: It is demonstrated that a non-telomeric isoform of telomere repeat-binding factor 2 (TRF2-S) is a novel RBP that regulates axonal plasticity and suggests a pivotal role for TRF1-S in an axonal mRNA localization pathway that enhances axon outgrowth and neurotransmitter release.
Journal ArticleDOI
Fragile X syndrome neurobiology translates into rational therapy.
Sien Braat,R. Frank Kooy +1 more
TL;DR: The targeted pathways converge in part with those of related neurodevelopmental disorders raising hopes that the treatments developed for this specific disorder might be more broadly applicable.
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Novel roles of amyloid-beta precursor protein metabolites in fragile X syndrome and autism.
TL;DR: The contribution of APP metabolites to FXS and autism pathogenesis as well as the potential use of these metabolites as blood-based biomarkers and therapeutic targets are discussed.
Journal ArticleDOI
Parallel Social Information Processing Circuits Are Differentially Impacted in Autism
Eastman M. Lewis,Genevieve Stein-O’Brien,Alejandra V. Patino,Romain Nardou,Cooper D. Grossman,Matthew P Brown,Bidii Bangamwabo,Ndeye Ndiaye,Daniel Giovinazzo,Ian Dardani,Connie L. Jiang,Loyal A. Goff,Gül Dölen +12 more
TL;DR: The first comprehensive characterization of magnocellular and parvocellular oxytocin neurons in male mice is provided, validated across anatomical, projection target, electrophysiological, and transcriptional criteria.
Journal ArticleDOI
Regional brain volumes changes in adult male FMR1-KO mouse on the FVB strain.
TL;DR: Brain volumes in FMR1 knockout male mice on a FVB background are examined using high resolution (multi-channel 7.0Tesla) MRI to observe multiple differences in the neuroanatomy and highlight the importance of genetic strain contribution to brain structure.
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TL;DR: In this paper, the authors present a model for the analysis of variance in a single-classification and two-way and multiway analysis of Variance with the assumption of correlation.
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