FMRP stalls ribosomal translocation on mRNAs linked to synaptic function and autism
Jennifer C. Darnell,Sarah J. Van Driesche,Chaolin Zhang,Ka Ying Sharon Hung,Aldo Mele,Claire E. Fraser,Elizabeth F. Stone,Cynthia Chen,John J. Fak,Sung Wook Chi,Donny D. Licatalosi,Joel D. Richter,Robert B. Darnell,Robert B. Darnell +13 more
TLDR
A brain polyribosome-programmed translation system is developed, revealing that FMRP reversibly stalls ribosomes specifically on its target mRNAs and suggests multiple targets for clinical intervention in FXS and ASD.About:
This article is published in Cell.The article was published on 2011-07-22 and is currently open access. It has received 1861 citations till now. The article focuses on the topics: FMR1 & RNA-binding protein.read more
Citations
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Differential Adulthood Onset mGlu5 Signaling Saves Prefrontal Function in the Fragile X Mouse.
Henry G. S. Martin,Henry G. S. Martin,Henry G. S. Martin,Olivier Lassalle,Olivier Lassalle,Olivier Lassalle,Olivier J. Manzoni,Olivier J. Manzoni,Olivier J. Manzoni +8 more
TL;DR: Examination of changes in mGlu5 function in the PFC in a mouse model of FXS (Fmr1 knockout) during early adulthood and subsequent maturity suggests when studying neurodevelopmental disorders with a significant PFC phenotype consideration of late onset changes may be important.
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The STEP61 interactome reveals subunit-specific AMPA receptor binding and synaptic regulation.
TL;DR: A comprehensive list of STEP61 binding partners is reported, including AMPARs, and a central role for STEP61 is revealed in differentially organizing synaptic AM PARs and NMDARs, which is mediated by lysosomal degradation.
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UBAP2L is amplified in a large subset of human lung adenocarcinoma and is critical for epithelial lung cell identity and tumor metastasis
Romain Aucagne,Simon Girard,Nadine Mayotte,Bernhard Lehnertz,Stéphane Lopes-Paciencia,Patrick Gendron,Geneviève Boucher,Jalila Chagraoui,Guy Sauvageau +8 more
TL;DR: It is suggested that UBAP2L contributes to epithelial lung cell identity in mice and that it plays an important role in human lung adenocarcinoma.
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RNA-binding protein research with transcriptome-wide technologies in neural development
TL;DR: This review highlights the discoveries and challenges of the interplay between the nRNABPs and their biological functions in neural development and identifies a dynamic range of RNA targets of RNABPs at the transcriptome-wide level.
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FMRP Associates with Cytoplasmic Granules at the Onset of Meiosis in the Human Oocyte.
Roseanne Rosario,Panagiotis Filis,Victoria Tessyman,Hazel L. Kinnell,Andrew J. Childs,Nicola K. Gray,Richard A. Anderson +6 more
TL;DR: The hypothesis that FMRP plays a role regulating mRNAs during pivotal maturational processes in fetal germ cells, and ovarian dysfunction resulting from FMR1 premutation may have its origins during these stages of oocyte development is supported.
References
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TL;DR: In this paper, the authors present a model for the analysis of variance in a single-classification and two-way and multiway analysis of Variance with the assumption of correlation.
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