FMRP stalls ribosomal translocation on mRNAs linked to synaptic function and autism
Jennifer C. Darnell,Sarah J. Van Driesche,Chaolin Zhang,Ka Ying Sharon Hung,Aldo Mele,Claire E. Fraser,Elizabeth F. Stone,Cynthia Chen,John J. Fak,Sung Wook Chi,Donny D. Licatalosi,Joel D. Richter,Robert B. Darnell,Robert B. Darnell +13 more
TLDR
A brain polyribosome-programmed translation system is developed, revealing that FMRP reversibly stalls ribosomes specifically on its target mRNAs and suggests multiple targets for clinical intervention in FXS and ASD.About:
This article is published in Cell.The article was published on 2011-07-22 and is currently open access. It has received 1861 citations till now. The article focuses on the topics: FMR1 & RNA-binding protein.read more
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Protein Translation in the Nucleus Accumbens Is Dysregulated during Cocaine Withdrawal and Required for Expression of Incubation of Cocaine Craving.
TL;DR: The hypothesis that translation is dysregulated during cocaine withdrawal and this contributes to incubated craving is tested, and it is demonstrated that the expression of incubation depends on an acute increase in translation that may result from dysregulation of several pathways.
Journal ArticleDOI
Interference of the complex between NCS-1 and Ric8a with phenothiazines regulates synaptic function and is an approach for fragile X syndrome.
Alicia Mansilla,Antonio Chaves-Sanjuan,Nuria E. Campillo,Ourania Semelidou,Loreto Martínez-González,Lourdes Infantes,Juana María González-Rubio,Carmen Gil,Santiago Conde,Efthimios M. C. Skoulakis,Alberto Ferrús,Ana Martínez,María José Sánchez-Barrena +12 more
TL;DR: A small molecule, the phenothiazine FD44, is identified that binds the interaction surface between NCS-1 and Ric8a, preventing the formation of the complex, and it restores normal synapse number and associative learning in a Drosophila FXS model.
Journal ArticleDOI
Spatially and temporally regulating translation via mRNA-binding proteins in cellular and neuronal function.
TL;DR: The robust and complex roles that mRNA‐binding proteins play in the regulation of local translation that impact cellular function in vertebrates are discussed and the expanding role for local protein synthesis in neuronal development and function is discussed.
Journal ArticleDOI
Genome wide assessment of mRNA in astrocyte protrusions by direct RNA sequencing reveals mRNA localization for the intermediate filament protein nestin
TL;DR: The correlated localization of Nestin mRNA with Nestin protein in cell protrusions indicates the presence of a regulatory mechanism at the mRNA localization level for the Nestin intermediate filament protein with potential importance for astrocyte functions during brain development and maintenance.
Journal ArticleDOI
A normal genetic variation modulates synaptic MMP-9 protein levels and the severity of schizophrenia symptoms
Katarzyna Lepeta,Katarzyna J. Purzycka,Katarzyna Pachulska-Wieczorek,Marina Mitjans,Martin Begemann,Behnam Vafadari,Krystian Bijata,Ryszard W. Adamiak,Hannelore Ehrenreich,Magdalena Dziembowska,Leszek Kaczmarek +10 more
TL;DR: A novel mechanism that involves M MP‐9‐dependent changes in dendritic spine morphology and the pathophysiology of schizophrenia is proposed, providing the first mechanistic insights into the way in which the single base change in the MMP‐9 gene (rs20544) influences gene function and results in phenotypic changes observed in schizophrenia patients.
References
More filters
Journal ArticleDOI
Controlling the false discovery rate: a practical and powerful approach to multiple testing
Yoav Benjamini,Yosef Hochberg +1 more
TL;DR: In this paper, a different approach to problems of multiple significance testing is presented, which calls for controlling the expected proportion of falsely rejected hypotheses -the false discovery rate, which is equivalent to the FWER when all hypotheses are true but is smaller otherwise.
Journal ArticleDOI
Systematic and integrative analysis of large gene lists using DAVID bioinformatics resources.
TL;DR: By following this protocol, investigators are able to gain an in-depth understanding of the biological themes in lists of genes that are enriched in genome-scale studies.
Biometery: The principles and practice of statistics in biological research
TL;DR: In this paper, the authors present a model for the analysis of variance in a single-classification and two-way and multiway analysis of Variance with the assumption of correlation.
Book
Biometry: The Principles and Practice of Statistics in Biological Research
Robert R. Sokal,F. James Rohlf +1 more
TL;DR: In this paper, the authors present a model for the analysis of variance in a single-classification and two-way and multiway analysis of Variance with the assumption of correlation.
Journal ArticleDOI
Linear Models and Empirical Bayes Methods for Assessing Differential Expression in Microarray Experiments
TL;DR: The hierarchical model of Lonnstedt and Speed (2002) is developed into a practical approach for general microarray experiments with arbitrary numbers of treatments and RNA samples and the moderated t-statistic is shown to follow a t-distribution with augmented degrees of freedom.
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