FMRP stalls ribosomal translocation on mRNAs linked to synaptic function and autism
Jennifer C. Darnell,Sarah J. Van Driesche,Chaolin Zhang,Ka Ying Sharon Hung,Aldo Mele,Claire E. Fraser,Elizabeth F. Stone,Cynthia Chen,John J. Fak,Sung Wook Chi,Donny D. Licatalosi,Joel D. Richter,Robert B. Darnell,Robert B. Darnell +13 more
TLDR
A brain polyribosome-programmed translation system is developed, revealing that FMRP reversibly stalls ribosomes specifically on its target mRNAs and suggests multiple targets for clinical intervention in FXS and ASD.About:
This article is published in Cell.The article was published on 2011-07-22 and is currently open access. It has received 1861 citations till now. The article focuses on the topics: FMR1 & RNA-binding protein.read more
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SMN-primed ribosomes modulate the translation of transcripts related to Spinal Muscular Atrophy
Fabio Lauria,Paola Bernabò,Toma Tebaldi,Toma Tebaldi,Ejn Groen,Elena Perenthaler,Massimiliano Clamer,Federica Maniscalco,Marta Marchioretto,Julia Orri,M Dalla Serra,Alberto Inga,Alessandro Quattrone,Thomas H. Gillingwater,Gabriella Viero +14 more
TL;DR: Survival Motor Neuron protein, loss of which causes the neuromuscular disease spinal muscular atrophy (SMA), binds to ribosomes and that this interaction is tissue-dependent, demonstrating a crucial role in the regulation of ribosome fluxes along mRNAs which encode proteins relevant to SMA pathogenesis.
Journal ArticleDOI
The frontier of RNA metamorphosis and ribosome signature in neocortical development
TL;DR: This review focuses on the regulatory role of the ribosome in neocortical development, and construct a current understanding of how ribosomal complex specificity may contribute to the development of the neocortex.
Journal ArticleDOI
Three decades of ASD genetics: building a foundation for neurobiological understanding and treatment.
TL;DR: In the case of autism spectrum disorders (ASD), microarrays, whole exome sequencing (WES) and whole genome sequencing have yielded over a hundred causal loci as mentioned in this paper.
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Normal CA1 place fields but discoordinated network discharge in a Fmr1-null mouse model of fragile X syndrome
Fraser T. Sparks,Zoe Nicole Talbot,Dino Dvorak,Bridget Mary Curran,Juan Marcos Alarcon,André A. Fenton +5 more
TL;DR: Findings point to invariant tuning of single-cell responses and inadequate discharge coordination within neural ensembles as a pathophysiological basis of cognitive inflexibility in FXS.
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Translational Regulation of NeuroD1 Expression by FMRP: Involvement in Glutamatergic Neuronal Differentiation of Cultured Rat Primary Neural Progenitor Cells
Se Jin Jeon,Ji-Woon Kim,Ki Chan Kim,So Min Han,Hyo Sang Go,Jung Eun Seo,Chang Soon Choi,Jong Hoon Ryu,Chan Young Shin,Mi-Ryoung Song +9 more
TL;DR: This study suggests that modulation of FMRP expression regulates neuronal differentiation by interaction with its binding target mRNA, and provides an example of the gene and environmental interaction regulating glutamatergic neuronal differentiation.
References
More filters
Journal ArticleDOI
Controlling the false discovery rate: a practical and powerful approach to multiple testing
Yoav Benjamini,Yosef Hochberg +1 more
TL;DR: In this paper, a different approach to problems of multiple significance testing is presented, which calls for controlling the expected proportion of falsely rejected hypotheses -the false discovery rate, which is equivalent to the FWER when all hypotheses are true but is smaller otherwise.
Journal ArticleDOI
Systematic and integrative analysis of large gene lists using DAVID bioinformatics resources.
TL;DR: By following this protocol, investigators are able to gain an in-depth understanding of the biological themes in lists of genes that are enriched in genome-scale studies.
Biometery: The principles and practice of statistics in biological research
TL;DR: In this paper, the authors present a model for the analysis of variance in a single-classification and two-way and multiway analysis of Variance with the assumption of correlation.
Book
Biometry: The Principles and Practice of Statistics in Biological Research
Robert R. Sokal,F. James Rohlf +1 more
TL;DR: In this paper, the authors present a model for the analysis of variance in a single-classification and two-way and multiway analysis of Variance with the assumption of correlation.
Journal ArticleDOI
Linear Models and Empirical Bayes Methods for Assessing Differential Expression in Microarray Experiments
TL;DR: The hierarchical model of Lonnstedt and Speed (2002) is developed into a practical approach for general microarray experiments with arbitrary numbers of treatments and RNA samples and the moderated t-statistic is shown to follow a t-distribution with augmented degrees of freedom.
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