FMRP stalls ribosomal translocation on mRNAs linked to synaptic function and autism
Jennifer C. Darnell,Sarah J. Van Driesche,Chaolin Zhang,Ka Ying Sharon Hung,Aldo Mele,Claire E. Fraser,Elizabeth F. Stone,Cynthia Chen,John J. Fak,Sung Wook Chi,Donny D. Licatalosi,Joel D. Richter,Robert B. Darnell,Robert B. Darnell +13 more
TLDR
A brain polyribosome-programmed translation system is developed, revealing that FMRP reversibly stalls ribosomes specifically on its target mRNAs and suggests multiple targets for clinical intervention in FXS and ASD.About:
This article is published in Cell.The article was published on 2011-07-22 and is currently open access. It has received 1861 citations till now. The article focuses on the topics: FMR1 & RNA-binding protein.read more
Citations
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FMRP Modulates Neural Differentiation through m6A-Dependent mRNA Nuclear Export.
Brittany M. Edens,Brittany M. Edens,Caroline Vissers,Jing Su,Jing Su,Saravanan Arumugam,Saravanan Arumugam,Zhaofa Xu,Zhaofa Xu,Han Shi,Han Shi,Nimrod Miller,Nimrod Miller,Francisca Rojas Ringeling,Guo Li Ming,Chuan He,Hongjun Song,Yong Chao Ma,Yong Chao Ma +18 more
TL;DR: It is shown that fragile X mental retardation protein (FMRP) reads m6A to promote nuclear export of methylated mRNA targets during neural differentiation, establishing a critical role for FMRP in mediating m 6A-dependent mRNA nuclear export during neural differentiate.
Journal ArticleDOI
Fundamental Elements in Autism: From Neurogenesis and Neurite Growth to Synaptic Plasticity.
James Gilbert,Heng-Ye Man +1 more
TL;DR: This review article focuses on the major genes and signaling pathways implicated in ASD and discusses the cellular, molecular and functional studies that have shed light on common dysregulated pathways using in vitro, in vivo and human evidence.
Journal ArticleDOI
Progress toward treatments for synaptic defects in autism
Richard Delorme,Elodie Ey,Elodie Ey,Elodie Ey,Roberto Toro,Roberto Toro,Roberto Toro,Marion Leboyer,Christopher Gillberg,Christopher Gillberg,Christopher Gillberg,Thomas Bourgeron +11 more
TL;DR: It is proposed, given the clinical heterogeneity of ASD, that specific 'synaptic clinical trials' should be designed and launched with the aim of establishing whether phenotype 'reversals' could also occur in humans.
Journal ArticleDOI
Synaptopathology Involved in Autism Spectrum Disorder.
TL;DR: Major genes and signaling pathways implicated in synaptic abnormalities underlying ASD are reviewed, and molecular, cellular and functional studies of ASD experimental models are discussed.
Fragile X mental retardation protein and synaptic plasticity
TL;DR: In healthy neurons, FMRP modulates the local translation of numerous synaptic proteins that are required for the maintenance and regulation of long-lasting changes in synaptic strength.
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