FMRP stalls ribosomal translocation on mRNAs linked to synaptic function and autism
Jennifer C. Darnell,Sarah J. Van Driesche,Chaolin Zhang,Ka Ying Sharon Hung,Aldo Mele,Claire E. Fraser,Elizabeth F. Stone,Cynthia Chen,John J. Fak,Sung Wook Chi,Donny D. Licatalosi,Joel D. Richter,Robert B. Darnell,Robert B. Darnell +13 more
TLDR
A brain polyribosome-programmed translation system is developed, revealing that FMRP reversibly stalls ribosomes specifically on its target mRNAs and suggests multiple targets for clinical intervention in FXS and ASD.About:
This article is published in Cell.The article was published on 2011-07-22 and is currently open access. It has received 1861 citations till now. The article focuses on the topics: FMR1 & RNA-binding protein.read more
Citations
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FMRP interacts with G-quadruplex structures in the 3'-UTR of its dendritic target Shank1 mRNA.
TL;DR: A role of G-quadruplex RNA motif as a structural element in the common mechanism of FMRP regulation of its dendritic mRNA targets is suggested.
Journal ArticleDOI
Fragile X mental retardation protein controls ion channel expression and activity.
TL;DR: Studies performed on animal models of fragile X syndrome have revealed links between modifications of ion channel activity and changes in neuronal excitability, suggesting that these modifications could contribute to the phenotypes observed in patients with fragile X‐associated disorders.
Journal ArticleDOI
BDNF in fragile X syndrome.
Maija L. Castrén,Eero Castrén +1 more
TL;DR: The evidence of the role for BDNF in the developing and adult FXS brain is reviewed, including abnormal differentiation of neural progenitors and impaired migration of newly born neurons.
Journal ArticleDOI
Identification of consensus binding sites clarifies FMRP binding determinants.
TL;DR: This comparative dataset revealed that of the various sequence and structural motifs that have been proposed to specify FMRP binding, the short sequence motifs TGGA and GAC were corroborated, and a novel TAY motif was identified.
Journal ArticleDOI
RNA topoisomerase is prevalent in all domains of life and associates with polyribosomes in animals
Muzammil Ahmad,Yutong Xue,Seung Kyu Lee,Jennifer L. Martindale,Weiping Shen,Wen Li,Sige Zou,Maria Ciaramella,Hélène Débat,Marc Nadal,Fenfei Leng,Hongliang Zhang,Quan Wang,Grace Ee-Lu Siaw,Hengyao Niu,Yves Pommier,Myriam Gorospe,Tao-shih Hsieh,Yuk-Ching Tse-Dinh,Dongyi Xu,Weidong Wang +20 more
TL;DR: It is proposed that RNA topoisomerases arose in the early RNA world, and that they are retained through all domains of DNA-based life, where they mediate mRNA translation as part of polyribosomes in animals.
References
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Biometry: The Principles and Practice of Statistics in Biological Research
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TL;DR: In this paper, the authors present a model for the analysis of variance in a single-classification and two-way and multiway analysis of Variance with the assumption of correlation.
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