FMRP stalls ribosomal translocation on mRNAs linked to synaptic function and autism
Jennifer C. Darnell,Sarah J. Van Driesche,Chaolin Zhang,Ka Ying Sharon Hung,Aldo Mele,Claire E. Fraser,Elizabeth F. Stone,Cynthia Chen,John J. Fak,Sung Wook Chi,Donny D. Licatalosi,Joel D. Richter,Robert B. Darnell,Robert B. Darnell +13 more
TLDR
A brain polyribosome-programmed translation system is developed, revealing that FMRP reversibly stalls ribosomes specifically on its target mRNAs and suggests multiple targets for clinical intervention in FXS and ASD.About:
This article is published in Cell.The article was published on 2011-07-22 and is currently open access. It has received 1861 citations till now. The article focuses on the topics: FMR1 & RNA-binding protein.read more
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Staufen2 Regulates Neuronal Target RNAs
Jacki E. Heraud-Farlow,Tejaswini Sharangdhar,Xiao Li,Philipp Pfeifer,Stefanie Tauber,Denise Orozco,Denise Orozco,Alexandra Hörmann,Sabine Thomas,Anetta Bakosova,Ashley Farlow,Dieter Edbauer,Dieter Edbauer,Howard D. Lipshitz,Quaid Morris,Martin Bilban,Michael P. Doyle,Michael A. Kiebler +17 more
TL;DR: The identification of functionally relevant Stau2 target mRNAs in neurons is reported, revealing a role in stabilization of the levels of synaptic targets and that its targets are predominantly downregulated in Stau1-deficient neurons.
Journal ArticleDOI
mRNA on the Move: The Road to Its Biological Destiny *□
TL;DR: This minireview focuses on the advanced biochemical and cell imaging techniques used to tweeze out the finer aspects of mechanisms of mRNA movement.
Journal ArticleDOI
Impaired activity-dependent neural circuit assembly and refinement in autism spectrum disorder genetic models
Caleb A. Doll,Kendal Broadie +1 more
TL;DR: Advances in Drosophila optogenetics, transgenic calcium reporters, highly-targeted transgenic drivers for individually-identified neurons, and a vastly improved connectome of the brain are now being combined to provide unparalleled opportunities to both manipulate and monitor A-D processes during critical period brain development in defined neural circuits.
Journal ArticleDOI
Tracking the Fragile X Mental Retardation Protein in a Highly Ordered Neuronal RiboNucleoParticles Population: A Link between Stalled Polyribosomes and RNA Granules
Rachid El Fatimy,Laetitia Davidovic,Sandra Tremblay,Xavier H. Jaglin,Alain Y. Dury,Claude Robert,Paul De Koninck,Edouard W. Khandjian +7 more
TL;DR: In this paper, a specific population of RNA granules from mouse brain homogenates were used as a tracer to identify the Fragile X Mental Retardation Protein (FMRP) protein.
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Mechanisms governing activity-dependent synaptic pruning in the developing mammalian CNS
TL;DR: A review of activity-dependent synaptic pruning in the mammalian central nervous system can be found in this paper where the authors discuss the mounting evidence that immune and cell-death molecules are important mechanistic links by which changes in neural activity guide the pruning of specific synapses, emphasizing the role of glial cells in this process.
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