FMRP stalls ribosomal translocation on mRNAs linked to synaptic function and autism
Jennifer C. Darnell,Sarah J. Van Driesche,Chaolin Zhang,Ka Ying Sharon Hung,Aldo Mele,Claire E. Fraser,Elizabeth F. Stone,Cynthia Chen,John J. Fak,Sung Wook Chi,Donny D. Licatalosi,Joel D. Richter,Robert B. Darnell,Robert B. Darnell +13 more
TLDR
A brain polyribosome-programmed translation system is developed, revealing that FMRP reversibly stalls ribosomes specifically on its target mRNAs and suggests multiple targets for clinical intervention in FXS and ASD.About:
This article is published in Cell.The article was published on 2011-07-22 and is currently open access. It has received 1861 citations till now. The article focuses on the topics: FMR1 & RNA-binding protein.read more
Citations
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Schizophrenia genetics in the genome-wide era: a review of Japanese studies.
Tetsufumi Kanazawa,Chad A. Bousman,Chad A. Bousman,Chenxing Liu,Ian P. Everall,Ian P. Everall +5 more
TL;DR: This invited review provides concise summaries of the schizophrenia genome-wide association study and copy number variant literature with specific focus on studies conducted in the Japanese population and concludes with recommendations for future research in schizophrenia genetics, relevant to Japan and beyond.
Journal ArticleDOI
Autism spectrum disorders and disease modeling using stem cells
Anita Brito,Fabiele Baldino Russo,Alysson R. Muotri,Patricia Cristina Baleeiro Beltrão-Braga +3 more
TL;DR: Induced pluripotent stem cell technology has been used to model several neurological diseases, including syndromic and non-syndromic autism and it is discussed how modeling the central nervous system cells in a dish may help to reach a better understanding of ASD pathology and variability.
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FMR1 and Autism, an Intriguing Connection Revisited
William Fyke,Milen Velinov +1 more
TL;DR: The most common single-gene disorder associated with ASD is Fragile X syndrome (FXS) as discussed by the authors, which results from the loss of function of FMR1 due to the expansion of an unstable CGG repeat located in the 5′′ untranslated region of the gene.
Journal ArticleDOI
The Atypical Dual Specificity Phosphatase hYVH1 Associates with Multiple Ribonucleoprotein Particles.
TL;DR: Results propagate a role for dual specificity phosphatases at RNP particles and suggest that hYVH1 may affect a variety of fundamental cellular processes by regulating messenger ribonucleoprotein (mRNP) dynamics.
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Reduced vagal tone in women with the FMR1 premutation is associated with FMR1 mRNA but not depression or anxiety
TL;DR: Unlike patterns observed in the general population and in study controls, vagal activity and depression symptoms were decoupled in women with the FMR1 premutation, suggesting independence between autonomic regulation and psychopathological symptoms that is atypical and potentially specific to the F MR1 premutations.
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