FMRP stalls ribosomal translocation on mRNAs linked to synaptic function and autism
Jennifer C. Darnell,Sarah J. Van Driesche,Chaolin Zhang,Ka Ying Sharon Hung,Aldo Mele,Claire E. Fraser,Elizabeth F. Stone,Cynthia Chen,John J. Fak,Sung Wook Chi,Donny D. Licatalosi,Joel D. Richter,Robert B. Darnell,Robert B. Darnell +13 more
TLDR
A brain polyribosome-programmed translation system is developed, revealing that FMRP reversibly stalls ribosomes specifically on its target mRNAs and suggests multiple targets for clinical intervention in FXS and ASD.About:
This article is published in Cell.The article was published on 2011-07-22 and is currently open access. It has received 1861 citations till now. The article focuses on the topics: FMR1 & RNA-binding protein.read more
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The Fragile X Mutation Impairs Homeostatic Plasticity in Human Neurons by Blocking Synaptic Retinoic-Acid Signaling
Zhenjie Zhang,Samuele Marro,Yingsha Zhang,Kristin L. Arendt,Christopher Patzke,Bo Zhou,Tyler Fair,Nan Yang,Thomas C. Südhof,Marius Wernig,Lu Chen +10 more
TL;DR: A robust functional impairment caused by FMR1 mutations that might contribute to neuronal dysfunction in FXS is revealed and it is demonstrated that, in human neurons, homeostatic plasticity induced by synaptic silencing was mediated by retinoic acid, which regulated both excited and inhibitory synaptic strength.
Journal ArticleDOI
Co-regulation of mRNA translation by TDP-43 and Fragile X Syndrome protein FMRP.
TL;DR: The study establishes a functional/physical partnership between FMRP and TDP-43 that mechanistically links several neurodevelopmental disorders and neurodegenerative diseases.
Journal ArticleDOI
A meta-analysis of gene expression quantitative trait loci in brain.
Yunjung Kim,Kai Xia,Ran Tao,Paola Giusti-Rodríguez,Vladimir I. Vladimirov,E J C G van den Oord,Patrick F. Sullivan +6 more
TL;DR: A meta-analysis of 424 brain samples across five studies found that significant eQTLs were more likely to be near 5’-untranslated regions and intersect with regulatory features, suggesting a potential role for common genetic variation influencing the robustness of energy supply in brain and a possible role in the etiology of some psychiatric disorders.
Journal ArticleDOI
Autism and Schizophrenia-Associated CYFIP1 Regulates the Balance of Synaptic Excitation and Inhibition.
Elizabeth C. Davenport,Blanka R. Szulc,James Drew,James Taylor,Toby Morgan,Nathalie F. Higgs,Guillermo López-Doménech,Josef T. Kittler +7 more
TL;DR: YFCIP1 dosage can bi-directionally impact inhibitory synaptic structure and function, potentially leading to altered E/I balance and circuit dysfunction in CYFIP1-associated neurological disorders.
Journal ArticleDOI
Loss of Wdfy3 in mice alters cerebral cortical neurogenesis reflecting aspects of the autism pathology
Lori Orosco,Adam P. Ross,Adam P. Ross,Staci L. Cates,Staci L. Cates,Sean E. Scott,Sean E. Scott,Dennis J. Wu,Jiho Sohn,David E Pleasure,Samuel J. Pleasure,Iannis E. Adamopoulos,Iannis E. Adamopoulos,Konstantinos Zarbalis,Konstantinos Zarbalis +14 more
TL;DR: The authors' analysis of affected mouse mutants defines an important role for Wdfy3 in regulating neural progenitor divisions and neural migration in the developing brain, which is essential to cerebral expansion and functional organization while its loss-of-function results in pathological changes characteristic of ASDs.
References
More filters
Journal ArticleDOI
Controlling the false discovery rate: a practical and powerful approach to multiple testing
Yoav Benjamini,Yosef Hochberg +1 more
TL;DR: In this paper, a different approach to problems of multiple significance testing is presented, which calls for controlling the expected proportion of falsely rejected hypotheses -the false discovery rate, which is equivalent to the FWER when all hypotheses are true but is smaller otherwise.
Journal ArticleDOI
Systematic and integrative analysis of large gene lists using DAVID bioinformatics resources.
TL;DR: By following this protocol, investigators are able to gain an in-depth understanding of the biological themes in lists of genes that are enriched in genome-scale studies.
Biometery: The principles and practice of statistics in biological research
TL;DR: In this paper, the authors present a model for the analysis of variance in a single-classification and two-way and multiway analysis of Variance with the assumption of correlation.
Book
Biometry: The Principles and Practice of Statistics in Biological Research
Robert R. Sokal,F. James Rohlf +1 more
TL;DR: In this paper, the authors present a model for the analysis of variance in a single-classification and two-way and multiway analysis of Variance with the assumption of correlation.
Journal ArticleDOI
Linear Models and Empirical Bayes Methods for Assessing Differential Expression in Microarray Experiments
TL;DR: The hierarchical model of Lonnstedt and Speed (2002) is developed into a practical approach for general microarray experiments with arbitrary numbers of treatments and RNA samples and the moderated t-statistic is shown to follow a t-distribution with augmented degrees of freedom.
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