FMRP stalls ribosomal translocation on mRNAs linked to synaptic function and autism
Jennifer C. Darnell,Sarah J. Van Driesche,Chaolin Zhang,Ka Ying Sharon Hung,Aldo Mele,Claire E. Fraser,Elizabeth F. Stone,Cynthia Chen,John J. Fak,Sung Wook Chi,Donny D. Licatalosi,Joel D. Richter,Robert B. Darnell,Robert B. Darnell +13 more
TLDR
A brain polyribosome-programmed translation system is developed, revealing that FMRP reversibly stalls ribosomes specifically on its target mRNAs and suggests multiple targets for clinical intervention in FXS and ASD.About:
This article is published in Cell.The article was published on 2011-07-22 and is currently open access. It has received 1861 citations till now. The article focuses on the topics: FMR1 & RNA-binding protein.read more
Citations
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The Fragile X Mental Retardation Protein Regulates Matrix Metalloproteinase 9 mRNA at Synapses
Aleksandra Janusz,Jacek Milek,Malgorzata Perycz,Laura Pacini,Claudia Bagni,Leszek Kaczmarek,Magdalena Dziembowska +6 more
TL;DR: It is proposed that a local effect of MMP-9 mRNA translation at synapses can contribute to the aberrant dendritic spine morphology observed in the Fmr1 knock-out mice and in patients with FXS.
Journal ArticleDOI
The Fragile X Protein binds mRNAs involved in cancer progression and modulates metastasis formation
Rossella Luca,Michele Averna,Francesca Zalfa,Manuela Vecchi,Fabrizio Bianchi,Giorgio La Fata,Franca Del Nonno,Roberta Nardacci,Marco Bianchi,Paolo Nuciforo,Sebastian Munck,Paola Parrella,Rute Moura,Emanuela Signori,Robert D. Alston,Anna Kuchnio,Maria Giulia Farace,Vito Michele Fazio,Vito Michele Fazio,Mauro Piacentini,Bart De Strooper,Tilmann Achsel,Giovanni Neri,Patrick Neven,D. Gareth Evans,Peter Carmeliet,Massimiliano Mazzone,Claudia Bagni +27 more
TL;DR: It is established that FMRP overexpression in murine breast primary tumours enhances lung metastasis while its reduction has the opposite effect regulating cell spreading and invasion.
Journal ArticleDOI
RNA-binding proteins in neurodegeneration: Seq and you shall receive.
Julia K. Nussbacher,Ranjan Batra,Clotilde Lagier-Tourenne,Clotilde Lagier-Tourenne,Gene W. Yeo,Gene W. Yeo +5 more
TL;DR: Development of high-throughput sequencing methodologies provides unparalleled potential to discover new mechanisms of disease-associated perturbations of RNA homeostasis, and complementary to candidate single-gene studies, these innovative technologies may elicit the discovery of unexpected mechanisms.
Journal ArticleDOI
Fragile X mental retardation 1 gene enhances the translation of large autism-related proteins.
TL;DR: Ribosome profiling of oocytes identified a specific role for FMR1 in enhancing the translation of large proteins, including many associated with autism, and acts preferentially on large proteins.
Journal ArticleDOI
The m6A-epitranscriptomic signature in neurobiology: from neurodevelopment to brain plasticity.
Jocelyn Widagdo,Victor Anggono +1 more
TL;DR: Insight is provided into the roles of m6A in regulating brain function, from development to synaptic plasticity, learning, and memory, and how aberrant m 6A signaling may contribute to neurodevelopmental and neuropsychiatric disorders.
References
More filters
Journal ArticleDOI
Controlling the false discovery rate: a practical and powerful approach to multiple testing
Yoav Benjamini,Yosef Hochberg +1 more
TL;DR: In this paper, a different approach to problems of multiple significance testing is presented, which calls for controlling the expected proportion of falsely rejected hypotheses -the false discovery rate, which is equivalent to the FWER when all hypotheses are true but is smaller otherwise.
Journal ArticleDOI
Systematic and integrative analysis of large gene lists using DAVID bioinformatics resources.
TL;DR: By following this protocol, investigators are able to gain an in-depth understanding of the biological themes in lists of genes that are enriched in genome-scale studies.
Biometery: The principles and practice of statistics in biological research
TL;DR: In this paper, the authors present a model for the analysis of variance in a single-classification and two-way and multiway analysis of Variance with the assumption of correlation.
Book
Biometry: The Principles and Practice of Statistics in Biological Research
Robert R. Sokal,F. James Rohlf +1 more
TL;DR: In this paper, the authors present a model for the analysis of variance in a single-classification and two-way and multiway analysis of Variance with the assumption of correlation.
Journal ArticleDOI
Linear Models and Empirical Bayes Methods for Assessing Differential Expression in Microarray Experiments
TL;DR: The hierarchical model of Lonnstedt and Speed (2002) is developed into a practical approach for general microarray experiments with arbitrary numbers of treatments and RNA samples and the moderated t-statistic is shown to follow a t-distribution with augmented degrees of freedom.
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