FMRP stalls ribosomal translocation on mRNAs linked to synaptic function and autism
Jennifer C. Darnell,Sarah J. Van Driesche,Chaolin Zhang,Ka Ying Sharon Hung,Aldo Mele,Claire E. Fraser,Elizabeth F. Stone,Cynthia Chen,John J. Fak,Sung Wook Chi,Donny D. Licatalosi,Joel D. Richter,Robert B. Darnell,Robert B. Darnell +13 more
TLDR
A brain polyribosome-programmed translation system is developed, revealing that FMRP reversibly stalls ribosomes specifically on its target mRNAs and suggests multiple targets for clinical intervention in FXS and ASD.About:
This article is published in Cell.The article was published on 2011-07-22 and is currently open access. It has received 1861 citations till now. The article focuses on the topics: FMR1 & RNA-binding protein.read more
Citations
More filters
Journal ArticleDOI
Role of a redox-based methylation switch in mRNA life cycle (pre- and post-transcriptional maturation) and protein turnover: implications in neurological disorders.
TL;DR: This review article provides some insight on the intriguing consequences of changes in methylation levels on mRNA life-cycle and suggests that, since methylation is under the control of glutathione anti-oxidant levels, the redox status of neurons might be the central regulatory switch for methylation-based changes in mRNA processing, protein expression, and turnover.
Journal ArticleDOI
Fragile X Mental Retardation Protein: To Be or Not to Be a Translational Enhancer.
Thomas Maurin,Barbara Bardoni +1 more
Journal ArticleDOI
Modelling fragile X syndrome in the laboratory setting: A behavioral perspective.
TL;DR: The aim of this review is to outline the importance of behavioral phenotyping of animal models of FXS from a developmental perspective, by showing how the behavioral characteristics ofFXS at the clinical level can be translated into effective, developmentally‐specific and clinically meaningful behavioral readouts in the laboratory setting.
Journal ArticleDOI
N-myristoylation regulates the axonal distribution of the Fragile X-related protein FXR2P.
TL;DR: Structural studies indicate that N-terminal myristoylation of the RNA binding protein FXR2P regulates its localization within the axonal arbor, and suggest that FXR 2P lipid modification is a control point for theAxonal and presynaptic distribution of FMRP.
Journal ArticleDOI
New Insights Into the Role of Cav2 Protein Family in Calcium Flux Deregulation in Fmr1-KO Neurons.
Sara Castagnola,Sébastien Delhaye,Alessandra Folci,Agnès Paquet,Frédéric Brau,Fabrice Duprat,Marielle Jarjat,Mauro Grossi,Méline Béal,Stéphane Martin,Massimo Mantegazza,Barbara Bardoni,Thomas Maurin +12 more
TL;DR: A new phenotype of cultured Fmr1-KO neurons is highlighted that can be considered a novel cellular biomarker and is amenable to small molecule screening and identification of new drugs to treat FXS.
References
More filters
Journal ArticleDOI
Controlling the false discovery rate: a practical and powerful approach to multiple testing
Yoav Benjamini,Yosef Hochberg +1 more
TL;DR: In this paper, a different approach to problems of multiple significance testing is presented, which calls for controlling the expected proportion of falsely rejected hypotheses -the false discovery rate, which is equivalent to the FWER when all hypotheses are true but is smaller otherwise.
Journal ArticleDOI
Systematic and integrative analysis of large gene lists using DAVID bioinformatics resources.
TL;DR: By following this protocol, investigators are able to gain an in-depth understanding of the biological themes in lists of genes that are enriched in genome-scale studies.
Biometery: The principles and practice of statistics in biological research
TL;DR: In this paper, the authors present a model for the analysis of variance in a single-classification and two-way and multiway analysis of Variance with the assumption of correlation.
Book
Biometry: The Principles and Practice of Statistics in Biological Research
Robert R. Sokal,F. James Rohlf +1 more
TL;DR: In this paper, the authors present a model for the analysis of variance in a single-classification and two-way and multiway analysis of Variance with the assumption of correlation.
Journal ArticleDOI
Linear Models and Empirical Bayes Methods for Assessing Differential Expression in Microarray Experiments
TL;DR: The hierarchical model of Lonnstedt and Speed (2002) is developed into a practical approach for general microarray experiments with arbitrary numbers of treatments and RNA samples and the moderated t-statistic is shown to follow a t-distribution with augmented degrees of freedom.
Related Papers (5)
The mGluR theory of fragile X mental retardation
Identification of a gene (FMR-1) containing a CGG repeat coincident with a breakpoint cluster region exhibiting length variation in fragile X syndrome
Annemiske J.M.H. Verkerk,Maura Pieretti,James S. Sutcliffe,Ying-Hui Fu,Derek P.A. Kuhl,Antonio Pizzuti,Orly Reiner,Stephen Richards,Maureen F. Victoria,Fuping Zhang,Bert Eussen,Gert-Jan B. van Ommen,Lau Blonden,Gregory J. Riggins,Jane L. Chastain,Catherine B. Kunst,Hans Galjaard,C. Thomas Caskey,David L. Nelson,Ben A. Oostra,Stephen T. Warren +20 more