FMRP stalls ribosomal translocation on mRNAs linked to synaptic function and autism
Jennifer C. Darnell,Sarah J. Van Driesche,Chaolin Zhang,Ka Ying Sharon Hung,Aldo Mele,Claire E. Fraser,Elizabeth F. Stone,Cynthia Chen,John J. Fak,Sung Wook Chi,Donny D. Licatalosi,Joel D. Richter,Robert B. Darnell,Robert B. Darnell +13 more
TLDR
A brain polyribosome-programmed translation system is developed, revealing that FMRP reversibly stalls ribosomes specifically on its target mRNAs and suggests multiple targets for clinical intervention in FXS and ASD.About:
This article is published in Cell.The article was published on 2011-07-22 and is currently open access. It has received 1861 citations till now. The article focuses on the topics: FMR1 & RNA-binding protein.read more
Citations
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Emerging roles for post-transcriptional regulation in circadian clocks
Chunghun Lim,Ravi Allada +1 more
TL;DR: It is hypothesize that post-transcriptional control confers on circadian clocks enhanced robustness as well as the ability to adapt to different environments.
Journal ArticleDOI
UNR/CSDE1 Drives a Post-transcriptional Program to Promote Melanoma Invasion and Metastasis.
Laurence Wurth,Panagiotis Papasaikas,David Olmeda,Nadine Bley,Guadalupe T. Calvo,Santiago Guerrero,Daniela Cerezo-Wallis,Javier Martinez-Useros,María García-Fernández,Stefan Hüttelmaier,Maria S. Soengas,Fátima Gebauer +11 more
TL;DR: It is shown that the RBP UNR/CSDE1 is overexpressed in melanoma tumors and promotes invasion and metastasis and is identified as an oncogenic modulator of melanoma progression.
Journal ArticleDOI
Emerging links between homeostatic synaptic plasticity and neurological disease.
Joyce Wondolowski,Dion Dickman +1 more
TL;DR: Recent studies that demonstrate homeostatic control of postsynaptic protein translation, retrograde signaling, and presynaptic function that may contribute to the etiology of complex neurological and psychiatric diseases are examined.
Journal ArticleDOI
Rare codons regulate KRas oncogenesis.
Benjamin L. Lampson,Nicole L.K. Pershing,Joseph A. Prinz,Joshua R. Lacsina,William F. Marzluff,Christopher V. Nicchitta,David M. MacAlpine,Christopher M. Counter +7 more
TL;DR: In a genome-wide survey, similar gene pairs with opposing codon bias were identified that not only manifest dichotomous protein expression but also are enriched in key signaling protein classes and pathways, suggesting a broader regulation strategy in cell signaling.
Journal ArticleDOI
Top3β is an RNA topoisomerase that works with fragile X syndrome protein to promote synapse formation
Dongyi Xu,Dongyi Xu,Weiping Shen,Rong Guo,Yutong Xue,Wei Peng,Jian Sima,Jay Yang,Alexei A. Sharov,Subramanya Srikantan,Jiandong Yang,David A. Fox,Yong Qian,Jennifer L. Martindale,Yulan Piao,James B. Machamer,Samit R Joshi,Subhasis Mohanty,Albert C. Shaw,Thomas E. Lloyd,Grant W. Brown,Minoru S.H. Ko,Myriam Gorospe,Sige Zou,Weidong Wang +24 more
TL;DR: The findings suggest that Top3β acts as an RNA topoisomerase and works with FMRP to promote the expression of mRNAs that are crucial for neurodevelopment and mental health.
References
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