FMRP stalls ribosomal translocation on mRNAs linked to synaptic function and autism
Jennifer C. Darnell,Sarah J. Van Driesche,Chaolin Zhang,Ka Ying Sharon Hung,Aldo Mele,Claire E. Fraser,Elizabeth F. Stone,Cynthia Chen,John J. Fak,Sung Wook Chi,Donny D. Licatalosi,Joel D. Richter,Robert B. Darnell,Robert B. Darnell +13 more
TLDR
A brain polyribosome-programmed translation system is developed, revealing that FMRP reversibly stalls ribosomes specifically on its target mRNAs and suggests multiple targets for clinical intervention in FXS and ASD.About:
This article is published in Cell.The article was published on 2011-07-22 and is currently open access. It has received 1861 citations till now. The article focuses on the topics: FMR1 & RNA-binding protein.read more
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Selective role of the catalytic PI3K subunit p110β in impaired higher order cognition in fragile X syndrome.
Christina Gross,Nisha Raj,Gemma Molinaro,Amanda G. Allen,Amanda G. Allen,Alonzo J. Whyte,Alonzo J. Whyte,Jay R. Gibson,Kimberly M. Huber,Shannon L. Gourley,Shannon L. Gourley,Gary J. Bassell +11 more
TL;DR: Genetic full-body reduction of p110β in Fmr1 knockout mice normalizes excessive PI3K activity, restores stimulus-induced protein synthesis, and corrects increased dendritic spine density and behavior.
Journal ArticleDOI
Behavioral neuroscience of autism.
TL;DR: It is proposed that spatiotemporal disturbances in brainstem development may be a primary cause of ASD that propagates towards the cerebral cortex, as well as the disruption in circadian rhythms and sleep that are observed in a subset of ASD.
Journal ArticleDOI
An RNA-centric dissection of host complexes controlling flavivirus infection.
Yaw Shin Ooi,Karim Majzoub,Karim Majzoub,Ryan A. Flynn,Miguel A. Mata,Jonathan Diep,Jason Kenichi Li,Nicholas van Buuren,Neil G. Rumachik,Alex G. Johnson,Andreas S. Puschnik,Caleb D. Marceau,Luwanika Mlera,Jeffrey M. Grabowski,Karla Kirkegaard,Marshall E. Bloom,Peter Sarnow,Carolyn R. Bertozzi,Carolyn R. Bertozzi,Jan E. Carette +19 more
TL;DR: A survey of the cellular RNA-binding proteins that interact with dengue virus and Zika virus genomic RNA identifies ribosome-binding protein 1 and vigilin as bona fide RBPs able to promote viral RNA translation, replication and stability.
Journal ArticleDOI
GABA receptor subunit distribution and FMRP–mGluR5 signaling abnormalities in the cerebellum of subjects with schizophrenia, mood disorders, and autism
S H Fatemi,Timothy D. Folsom +1 more
TL;DR: Postmortem data on GABA receptors, FMRP, and mGluR5 levels are discussed and the potential for new therapeutic interventions that target these interconnected signaling systems are compared.
Journal ArticleDOI
Cell-Type-Specific Translation Profiling Reveals a Novel Strategy for Treating Fragile X Syndrome
Sophie R. Thomson,Sang S. Seo,Stephanie A. Barnes,Susana R. Louros,Melania Muscas,Owen Dando,Caoimhe Kirby,David J. A. Wyllie,Giles E. Hardingham,Peter C. Kind,Emily K. Osterweil +10 more
TL;DR: Surprisingly, enhancement rather than inhibition of M4 activity normalizes core phenotypes in the Fmr1−/y, including excessive protein synthesis, exaggerated mGluR-LTD, and audiogenic seizures.
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