FMRP stalls ribosomal translocation on mRNAs linked to synaptic function and autism
Jennifer C. Darnell,Sarah J. Van Driesche,Chaolin Zhang,Ka Ying Sharon Hung,Aldo Mele,Claire E. Fraser,Elizabeth F. Stone,Cynthia Chen,John J. Fak,Sung Wook Chi,Donny D. Licatalosi,Joel D. Richter,Robert B. Darnell,Robert B. Darnell +13 more
TLDR
A brain polyribosome-programmed translation system is developed, revealing that FMRP reversibly stalls ribosomes specifically on its target mRNAs and suggests multiple targets for clinical intervention in FXS and ASD.About:
This article is published in Cell.The article was published on 2011-07-22 and is currently open access. It has received 1861 citations till now. The article focuses on the topics: FMR1 & RNA-binding protein.read more
Citations
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Journal ArticleDOI
mTOR and MAPK: from localized translation control to epilepsy.
TL;DR: It is proposed that mTOR and MAPK regulate RBPs, thereby guiding the local expression of their target-mRNAs encoding for markers of epilepsy, leading to hyperexcitability.
Journal ArticleDOI
Autism-Misregulated eIF4G Microexons Control Synaptic Translation and Higher Order Cognitive Functions.
Thomas Gonatopoulos-Pournatzis,Rieko Niibori,Eric W Salter,Robert J. Weatheritt,Brian Tsang,Shaghayegh Farhangmehr,Xinyi Liang,Ulrich Braunschweig,Jonathan Roth,Shen Zhang,Tyler Henderson,Eesha Sharma,Mathieu Quesnel-Vallières,Jon Permanyer,Stefan Maier,John Georgiou,Manuel Irimia,Nahum Sonenberg,Julie D. Forman-Kay,Anne-Claude Gingras,Anne-Claude Gingras,Graham L. Collingridge,Melanie A. Woodin,Sabine P. Cordes,Sabine P. Cordes,Benjamin J. Blencowe +25 more
TL;DR: Evidence is provided that the eIF4G microexons function as a translational brake by causing ribosome stalling, through their propensity to promote the coalescence of cytoplasmic granule components associated with translation repression, including the fragile X mental retardation protein FMRP.
Journal ArticleDOI
Fragile mental retardation protein interacts with the RNA-binding protein Caprin1 in neuronal ribonucleoprotein complexes
Rachid El Fatimy,Sandra Tremblay,Alain Y. Dury,Samuel Solomon,Paul De Koninck,John W. Schrader,Edouard W. Khandjian +6 more
TL;DR: In vivo and in vitro evidence show that Caprin1 interacts with FMRP at the level of the translation machinery as well as in trafficking neuronal granules, and it is proposed that protein interactors might modulate FMRp functions.
Journal ArticleDOI
Ribosome heterogeneity in stem cells and development
TL;DR: An updated overview of ribosome heterogeneity and its functional implications in selective mRNA translational control in stem cells and development is presented.
Journal ArticleDOI
Normal CA1 Place Fields but Discoordinated Network Discharge in a Fmr1-Null Mouse Model of Fragile X Syndrome.
Zoe Nicole Talbot,Fraser T. Sparks,Dino Dvorak,Bridget Mary Curran,Juan Marcos Alarcon,André A. Fenton,André A. Fenton,André A. Fenton +7 more
TL;DR: Findings point to invariant tuning of single-cell responses and inadequate discharge coordination within neural ensembles as a pathophysiological basis of cognitive inflexibility in FXS.
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