FMRP stalls ribosomal translocation on mRNAs linked to synaptic function and autism
Jennifer C. Darnell,Sarah J. Van Driesche,Chaolin Zhang,Ka Ying Sharon Hung,Aldo Mele,Claire E. Fraser,Elizabeth F. Stone,Cynthia Chen,John J. Fak,Sung Wook Chi,Donny D. Licatalosi,Joel D. Richter,Robert B. Darnell,Robert B. Darnell +13 more
TLDR
A brain polyribosome-programmed translation system is developed, revealing that FMRP reversibly stalls ribosomes specifically on its target mRNAs and suggests multiple targets for clinical intervention in FXS and ASD.About:
This article is published in Cell.The article was published on 2011-07-22 and is currently open access. It has received 1861 citations till now. The article focuses on the topics: FMR1 & RNA-binding protein.read more
Citations
More filters
Journal ArticleDOI
Drosophila Studies on Autism Spectrum Disorders.
TL;DR: Drosophila studies on ASD genes that regulate synaptogenesis, synaptic function, and synaptic plasticity through modulating chromatin remodeling, transcription, protein synthesis and degradation, cytoskeleton dynamics, andsynaptic scaffolding are reviewed.
Journal ArticleDOI
Increased Calcium Influx through L-type Calcium Channels in Human and Mouse Neural Progenitors Lacking Fragile X Mental Retardation Protein
Claudia Elisabetta Danesi,Venkat Swaroop Achuta,Pádraic Corcoran,Ulla-Kaisa Peteri,Giorgio Turconi,Nobuaki Matsui,Ilyas Albayrak,Veronika Rezov,Anders Isaksson,Maija L. Castrén +9 more
TL;DR: It is shown that intracellular calcium responses to depolarization are augmented in neural progenitors derived from human induced pluripotent stem cells and mouse brain with FXS, and developmental effects of increased calcium influx via L-type Cav channels in FXS neural progensitors are shown.
Journal ArticleDOI
RNA Secondary Structure Modulates FMRP's Bi-Functional Role in the MicroRNA Pathway.
Phillip J. Kenny,Stephanie Ceman +1 more
TL;DR: This review discusses the RNA binding protein Fragile X Mental Retardation Protein (FMRP) and its role in microRNA-mediated translational regulation, which is dependent on FMRP’s interaction with the RNA helicase Moloney leukemia virus 10 (MOV10), which modifies the structural landscape of bound mRNA, therefore facilitating or inhibiting its association with theRNA-Induced Silencing Complex.
Journal ArticleDOI
Risks and Recommendations in Prenatally Detected De Novo Balanced Chromosomal Rearrangements from Assessment of Long-Term Outcomes.
Christina Halgren,Nete Munk Nielsen,Lusine Nazaryan-Petersen,Asli Silahtaroglu,Ryan L. Collins,Ryan L. Collins,Chelsea Lowther,Chelsea Lowther,Susanne Kjaergaard,Morten Frisch,Maria Kirchhoff,Karen Brøndum-Nielsen,Allan Lind-Thomsen,Yuan Mang,Zahra El-Schich,Claire A. Boring,Mana M. Mehrjouy,Peter Jensen,Christina Fagerberg,Lotte Nylandsted Krogh,Jan Hansen,Thue Bryndorf,Claus Hansen,Michael E. Talkowski,Mads Bak,Mads Bak,Niels Tommerup,Iben Bache,Iben Bache +28 more
TL;DR: Sequencing of the chromosomal breakpoints as the first-tier diagnostic test in pregnancies with a de novo BCR is recommended and the previous estimates of Warburton to a morbidity risk of 27% are upwardly revised.
Journal ArticleDOI
Regulation of neuronal gene expression by local axonal translation.
TL;DR: The remarkable progress made in recent years to identify and characterize axonal phenomena including axon pathfinding, mitochondrial function, and synapse-specific plasticity is reviewed.
References
More filters
Journal ArticleDOI
Controlling the false discovery rate: a practical and powerful approach to multiple testing
Yoav Benjamini,Yosef Hochberg +1 more
TL;DR: In this paper, a different approach to problems of multiple significance testing is presented, which calls for controlling the expected proportion of falsely rejected hypotheses -the false discovery rate, which is equivalent to the FWER when all hypotheses are true but is smaller otherwise.
Journal ArticleDOI
Systematic and integrative analysis of large gene lists using DAVID bioinformatics resources.
TL;DR: By following this protocol, investigators are able to gain an in-depth understanding of the biological themes in lists of genes that are enriched in genome-scale studies.
Biometery: The principles and practice of statistics in biological research
TL;DR: In this paper, the authors present a model for the analysis of variance in a single-classification and two-way and multiway analysis of Variance with the assumption of correlation.
Book
Biometry: The Principles and Practice of Statistics in Biological Research
Robert R. Sokal,F. James Rohlf +1 more
TL;DR: In this paper, the authors present a model for the analysis of variance in a single-classification and two-way and multiway analysis of Variance with the assumption of correlation.
Journal ArticleDOI
Linear Models and Empirical Bayes Methods for Assessing Differential Expression in Microarray Experiments
TL;DR: The hierarchical model of Lonnstedt and Speed (2002) is developed into a practical approach for general microarray experiments with arbitrary numbers of treatments and RNA samples and the moderated t-statistic is shown to follow a t-distribution with augmented degrees of freedom.
Related Papers (5)
The mGluR theory of fragile X mental retardation
Identification of a gene (FMR-1) containing a CGG repeat coincident with a breakpoint cluster region exhibiting length variation in fragile X syndrome
Annemiske J.M.H. Verkerk,Maura Pieretti,James S. Sutcliffe,Ying-Hui Fu,Derek P.A. Kuhl,Antonio Pizzuti,Orly Reiner,Stephen Richards,Maureen F. Victoria,Fuping Zhang,Bert Eussen,Gert-Jan B. van Ommen,Lau Blonden,Gregory J. Riggins,Jane L. Chastain,Catherine B. Kunst,Hans Galjaard,C. Thomas Caskey,David L. Nelson,Ben A. Oostra,Stephen T. Warren +20 more