Global, regional, and national disease burden estimates of acute lower respiratory infections due to respiratory syncytial virus in young children in 2015: a systematic review and modelling study
Ting Shi,David A. McAllister,Katherine L. O'Brien,Eric A. F. Simões,Shabir A. Madhi,Bradford D. Gessner,Fernando P. Polack,Evelyn Balsells,Sozinho Acácio,Claudia Aguayo,Issifou Alassani,Asad Ali,Martin Antonio,Shally Awasthi,Juliet O. Awori,Eduardo Azziz-Baumgartner,Eduardo Azziz-Baumgartner,Henry C. Baggett,Vicky L. Baillie,Angel Balmaseda,Alfredo Barahona,Sudha Basnet,Sudha Basnet,Quique Bassat,Quique Bassat,Wilma Basualdo,Godfrey Bigogo,Louis Bont,Robert F. Breiman,W. Abdullah Brooks,W. Abdullah Brooks,Shobha Broor,Nigel Bruce,Dana Bruden,Philippe Buchy,Stuart Campbell,Phyllis Carosone-Link,Mandeep S. Chadha,James Chipeta,Monidarin Chou,Wilfrido Clara,Cheryl Cohen,Cheryl Cohen,Elizabeth de Cuellar,Duc Anh Dang,Budragchaagiin Dash-Yandag,Maria Deloria-Knoll,Mukesh Dherani,Tekchheng Eap,Bernard E. Ebruke,Marcela Echavarria,Carla Cecília de Freitas Lázaro Emediato,Rodrigo Fasce,Daniel R. Feikin,Luzhao Feng,Angela Gentile,Aubree Gordon,Doli Goswami,Doli Goswami,Sophie Goyet,Michelle J. Groome,Natasha B. Halasa,Siddhivinayak Hirve,Nusrat Homaira,Nusrat Homaira,Stephen R. C. Howie,Stephen R. C. Howie,Stephen R. C. Howie,Jorge Jara,Imane Jroundi,Cissy B. Kartasasmita,Najwa Khuri-Bulos,Karen L. Kotloff,Anand Krishnan,Romina Libster,Romina Libster,Olga Lopez,Marilla G. Lucero,Florencia Lución,Socorro Lupisan,Debora N. Marcone,John P. McCracken,Mario Mejia,Jennifer C. Moïsi,Joel M. Montgomery,David P. Moore,Cinta Moraleda,Jocelyn Moyes,Jocelyn Moyes,Patrick K. Munywoki,Patrick K. Munywoki,Kuswandewi Mutyara,Mark P. Nicol,D. James Nokes,D. James Nokes,Pagbajabyn Nymadawa,Maria Tereza da Costa Oliveira,Histoshi Oshitani,Nitin Pandey,Gláucia Paranhos-Baccalà,Lia Neu Phillips,Valentina Picot,Mustafizur Rahman,Mala Rakoto-Andrianarivelo,Zeba A Rasmussen,Barbara Rath,Annick Robinson,Candice Romero,Graciela Russomando,Vahid Salimi,Pongpun Sawatwong,Nienke M Scheltema,Brunhilde Schweiger,J. Anthony G. Scott,J. Anthony G. Scott,Phil Seidenberg,Kunling Shen,Rosalyn J. Singleton,Rosalyn J. Singleton,Viviana Sotomayor,Tor A. Strand,Tor A. Strand,Agustinus Sutanto,Mariam Sylla,Milagritos D. Tapia,Somsak Thamthitiwat,Elizabeth Thomas,Rafal Tokarz,Claudia Turner,Marietjie Venter,Sunthareeya Waicharoen,Jianwei Wang,Wanitda Watthanaworawit,Lay-Myint Yoshida,Hongjie Yu,Heather J. Zar,Harry Campbell,Harish Nair,Harish Nair +138 more
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TLDR
In this paper, the authors estimated the incidence and hospital admission rate of RSV-associated acute lower respiratory infection (RSV-ALRI) in children younger than 5 years stratified by age and World Bank income regions.About:
This article is published in The Lancet.The article was published on 2017-09-02 and is currently open access. It has received 1470 citations till now. The article focuses on the topics: Disease burden & Case fatality rate.read more
Citations
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Estimates of the global, regional, and national morbidity, mortality, and aetiologies of lower respiratory infections in 195 countries, 1990-2016: a systematic analysis for the Global Burden of Disease Study 2016
Christopher Troeger,Brigette F. Blacker,Ibrahim A Khalil,Puja C Rao,Jackie Cao,Stephanie R M Zimsen,Samuel B. Albertson,Aniruddha Deshpande,Tamer H. Farag,Zegeye Abebe,Ifedayo M. O. Adetifa,Ifedayo M. O. Adetifa,Tara Ballav Adhikari,Mohammed Akibu,Faris Lami,Ayman Al-Eyadhy,Nelson Alvis-Guzman,Azmeraw T. Amare,Azmeraw T. Amare,Yaw Ampem Amoako,Carl Abelardo T. Antonio,Olatunde Aremu,Ephrem Tsegay Asfaw,Solomon Weldegebreal Asgedom,Tesfay Mehari Atey,Engi F. Attia,Euripide Frinel G Arthur Avokpaho,Henok Tadesse Ayele,Tambe B Ayuk,Kalpana Balakrishnan,Aleksandra Barac,Quique Bassat,Masoud Behzadifar,Meysam Behzadifar,Soumyadeep Bhaumik,Zulfiqar A Bhutta,Zulfiqar A Bhutta,Ali Bijani,Michael Brauer,Michael Brauer,Alexandria Brown,Paulo Augusto Moreira Camargos,Carlos A Castañeda-Orjuela,Danny V. Colombara,Sara Conti,Abel Fekadu Dadi,Abel Fekadu Dadi,Lalit Dandona,Lalit Dandona,Rakhi Dandona,Rakhi Dandona,Huyen Phuc Do,Huyen Phuc Do,Eleonora Dubljanin,Dumessa Edessa,Hajer Elkout,Aman Yesuf Endries,Daniel Obadare Fijabi,Kyle J Foreman,Mohammad H. Forouzanfar,Nancy Fullman,Alberto L. García-Basteiro,Bradford D. Gessner,Peter W. Gething,Rashmi Gupta,Tarun Gupta,Gessessew Bugssa Hailu,Hamid Yimam Hassen,Mohammad Taghi Hedayati,Mohsen Heidari,Desalegn Tsegaw Hibstu,Nobuyuki Horita,Olayinka Stephen Ilesanmi,Mihajlo Jakovljevic,Amr Jamal,Amaha Kahsay,Amir Kasaeian,Dessalegn H. Kassa,Yousef Khader,Ejaz Ahmad Khan,Nuruzzaman Khan,Young-Ho Khang,Yun Jin Kim,Niranjan Kissoon,Luke D. Knibbs,Sonali Kochhar,Parvaiz A Koul,G Anil Kumar,Rakesh Lodha,Hassan Magdy Abd El Razek,Deborah Carvalho Malta,Joseph L. Mathew,Desalegn Tadese Mengistu,Haftay Berhane Mezgebe,Karzan Abdulmuhsin Mohammad,Mohammed A Mohammed,Fatemeh Momeniha,Srinivas Murthy,Cuong Tat Nguyen,Katie R Nielsen,Dina Nur Anggraini Ningrum,Yirga Legesse Nirayo,Eyal Oren,Justin R. Ortiz,Padukudru Anand Mahesh,Maarten J. Postma,Mostafa Qorbani,Reginald Quansah,Rajesh Kumar Rai,Saleem M Rana,Chhabi Lal Ranabhat,Sarah E Ray,Mohammad Sadegh Rezai,George Mugambage Ruhago,Saeid Safiri,Joshua A. Salomon,Benn Sartorius,Miloje Savic,Monika Sawhney,Jun She,Aziz Sheikh,Mekonnen Sisay Shiferaw,Mika Shigematsu,Jasvinder A. Singh,Ranjani Somayaji,Jeffrey D. Stanaway,Mu'awiyyah Babale Sufiyan,Getachew Redae Taffere,Mohamad-Hani Temsah,Matthew Thompson,Ruoyan Tobe-Gai,Roman Topor-Madry,Bach Xuan Tran,Tung Thanh Tran,Kald Beshir Tuem,Kingsley N. Ukwaja,Stein Emil Vollset,Judd L. Walson,Fitsum Weldegebreal,Andrea Werdecker,T. Eoin West,Naohiro Yonemoto,Maysaa El Sayed Zaki,Lei Zhou,Sanjay Zodpey,Theo Vos,Mohsen Naghavi,Stephen S Lim,Ali H. Mokdad,Christopher J L Murray,Simon I. Hay,Robert Reiner +151 more
TL;DR: The findings show substantial progress in the reduction of lower respiratory infection burden, but this progress has not been equal across locations, has been driven by decreases in several primary risk factors, and might require more effort among elderly adults.
Journal ArticleDOI
mRNA vaccines for infectious diseases: principles, delivery and clinical translation.
TL;DR: In 2019, the COVID-19 pandemic catalysed the most rapid vaccine development in history, with mRNA vaccines at the forefront of those efforts as mentioned in this paper, and although it is now clear that mRNA vaccines can rapidly and safely protect patients from infectious disease, additional research is required to optimize mRNA design, intracellular delivery and applications beyond SARS-CoV-2 prophylaxis.
Journal ArticleDOI
The respiratory syncytial virus vaccine landscape: lessons from the graveyard and promising candidates.
Natalie I Mazur,Deborah Higgins,Marta C. Nunes,José A. Melero,Annefleur C Langedijk,Nicole Horsley,Ursula J. Buchholz,Peter J. M. Openshaw,Jason S. McLellan,Janet A. Englund,Asuncion Mejias,Ruth A. Karron,Eric A. F. Simões,Ivana Knezevic,Octavio Ramilo,Pedro A Piedra,Helen Y. Chu,Ann R. Falsey,Harish Nair,Leyla Kragten-Tabatabaie,Anne Greenough,Eugenio Baraldi,Nikolaos G. Papadopoulos,Johan Vekemans,Fernando P. Polack,Mair Powell,Ashish Satav,Edward E. Walsh,Renato T. Stein,Barney S. Graham,Louis Bont +30 more
TL;DR: This Review provides a comprehensive overview of RSV vaccine candidates and mAbs in clinical development to prevent one of the most common and severe infectious diseases in young children and older adults worldwide.
Journal ArticleDOI
Immune responses to SARS-CoV-2 infection in hospitalized pediatric and adult patients.
Carl A. Pierce,Paula Preston-Hurlburt,Yile Dai,Clare Burn Aschner,Natalia Cheshenko,Benjamin T. Galen,Scott J. Garforth,Natalia G. Herrera,Rohit K. Jangra,Nicholas C. Morano,Erika P. Orner,Sharlene Sy,Kartik Chandran,James Dziura,Steven C. Almo,Aaron M. Ring,Marla J. Keller,Kevan C. Herold,Betsy C. Herold +18 more
TL;DR: The findings suggest that the poor outcome in hospitalized adults with COVID-19 compared to children may not be attributable to a failure to generate adaptive immune responses, and age-dependent factors may modulate the antiviral immune response.
Journal ArticleDOI
Estimates of the Burden of Group B Streptococcal Disease Worldwide for Pregnant Women, Stillbirths, and Children.
Anna C. Seale,Fiorella Bianchi-Jassir,Neal Russell,Maya Kohli-Lynch,Cally J Tann,Jenny Hall,Lola Madrid,Hannah Blencowe,Simon Cousens,Carol J Baker,Linda Bartlett,Clare L. Cutland,Michael G. Gravett,Paul T. Heath,Margaret Ip,Kirsty Le Doare,Kirsty Le Doare,Shabir A. Madhi,Craig E. Rubens,Samir K. Saha,Stephanie J. Schrag,Ajoke Sobanjo-ter Meulen,Johan Vekemans,Joy E Lawn +23 more
TL;DR: These first estimates show the magnitude and the potential impact of maternal vaccination against Group B Streptococcus in pregnant women, stillbirth, and infants.
References
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Aetiological role of common respiratory viruses in acute lower respiratory infections in children under five years: A systematic review and meta–analysis
TL;DR: A systematic literature review of case–control studies published from 1990 to 2014 supports RSV, IFV, PIV, MPV and RV as important causes of ALRI in young children, and provides quantitative estimates of the absolute proportion of virus–associated ALRI cases to which a viral cause can be attributed.
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The prevalence of hypoxaemia among ill children in developing countries: a systematic review
Rami Subhi,Matthew Adamson,Harry Campbell,Martin Weber,Katherine R. Smith,Trevor Duke,Trevor Duke +6 more
TL;DR: There is a need for increased awareness of the burden of hypoxaemia in childhood illness, mainly due to the low accuracy of clinical predictors and the limited availability of pulse oximetry for more accurate detection and oxygen for treatment.
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WHO consultation on Respiratory Syncytial Virus Vaccine Development Report from a World Health Organization Meeting held on 23-24 March 2015.
TL;DR: The World Health Organization convened the first RSV vaccine consultation in 15 years on the 23rd and 24th of March, 2015 in Geneva, Switzerland to provide guidance on clinical endpoints and development pathways for vaccine trials with a focus on considerations of low- and middle-income countries.
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Association between Respiratory Syncytial Virus Activity and Pneumococcal Disease in Infants: A Time Series Analysis of US Hospitalization Data
TL;DR: Daniel Weinberger and colleagues examine a possible interaction between two serious respiratory infections in children under 2 years of age and find no link between these infections and serious illness.
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Respiratory syncytial virus infection and disease in infants and young children observed from birth in Kilifi district Kenya.
David James Nokes,Emelda A. Okiro,Mwanajuma Ngama,Rachel Ochola,Lisa J. White,Paul D. Scott,Mike English,Mike English,Patricia A. Cane,Graham F. Medley +9 more
TL;DR: RSV accounts for a substantial proportion of the total respiratory disease in this rural population in Kenya and the majority of this morbidity occurs during late infancy and early childhood--ages at which the risk of disease following infection remains significant.
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