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Global, regional, and national disease burden estimates of acute lower respiratory infections due to respiratory syncytial virus in young children in 2015: a systematic review and modelling study

Ting Shi, +138 more
- 02 Sep 2017 - 
- Vol. 390, Iss: 10098, pp 946-958
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TLDR
In this paper, the authors estimated the incidence and hospital admission rate of RSV-associated acute lower respiratory infection (RSV-ALRI) in children younger than 5 years stratified by age and World Bank income regions.
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This article is published in The Lancet.The article was published on 2017-09-02 and is currently open access. It has received 1470 citations till now. The article focuses on the topics: Disease burden & Case fatality rate.

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Development of a Nomogram for Predicting Massive Necrotizing Pneumonia in Children

TL;DR: Wang et al. as mentioned in this paper used least absolute shrinkage and selection operator (LASSO) regression and multivariate logistic regression models to analyze the influencing factors of massive necrotizing pneumonia in children.
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Viral lower respiratory tract infections—strict admission guidelines for young children can safely reduce admissions

TL;DR: In this article, the authors performed a single-center retrospective administrative database search and medical record review to evaluate the safety and efficacy of admission guidelines for VLRTI and found that after the implementation of admission criteria, there were few adverse events and a significant reduction in admissions to the hospital from the emergency department.
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Chimeric Measles Virus (MV/RSV), Having Ectodomains of Respiratory Syncytial Virus (RSV) F and G Proteins Instead of Measles Envelope Proteins, Induced Protective Antibodies against RSV.

TL;DR: In this article, the ectodomains of measles fusion and hemagglutinin (HA) proteins were replaced with those of RSV F and G proteins, and a chimeric MV/RSV vaccine was developed.
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Critical Care Thresholds in Children with Bronchiolitis.

TL;DR: More children are being admitted to intensive care over time with increased costs, and comparing and aligning admissions is difficult as there are no standardized criteria.
Posted ContentDOI

Neutrophil: Airway Epithelial Interactions Result in Increased Epithelial Damage and Viral Clearance during RSV Infection

TL;DR: Using an in vitro model of the differentiated airway epithelium, it is found that addition of physiological concentrations of neutrophils to RSV infected nasal cultures was associated with greater epithelial damage with lower ciliary activity, cilia loss, less tight junction expression and more detachment of epithelial cells than seen with RSV infection alone.
References
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Journal ArticleDOI

Meta-Analysis in Clinical Trials*

TL;DR: This paper examines eight published reviews each reporting results from several related trials in order to evaluate the efficacy of a certain treatment for a specified medical condition and suggests a simple noniterative procedure for characterizing the distribution of treatment effects in a series of studies.
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Global, regional, and national life expectancy, all-cause mortality, and cause-specific mortality for 249 causes of death, 1980–2015: a systematic analysis for the Global Burden of Disease Study 2015

Haidong Wang, +844 more
- 08 Oct 2016 - 
TL;DR: The Global Burden of Disease 2015 Study provides a comprehensive assessment of all-cause and cause-specific mortality for 249 causes in 195 countries and territories from 1980 to 2015, finding several countries in sub-Saharan Africa had very large gains in life expectancy, rebounding from an era of exceedingly high loss of life due to HIV/AIDS.
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Global, regional, and national causes of child mortality in 2000-13, with projections to inform post-2015 priorities: an updated systematic analysis.

TL;DR: The authors' projection results provide concrete examples of how the distribution of child causes of deaths could look in 15-20 years to inform priority setting in the post-2015 era.
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