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Global, regional, and national disease burden estimates of acute lower respiratory infections due to respiratory syncytial virus in young children in 2015: a systematic review and modelling study

Ting Shi, +138 more
- 02 Sep 2017 - 
- Vol. 390, Iss: 10098, pp 946-958
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TLDR
In this paper, the authors estimated the incidence and hospital admission rate of RSV-associated acute lower respiratory infection (RSV-ALRI) in children younger than 5 years stratified by age and World Bank income regions.
About: 
This article is published in The Lancet.The article was published on 2017-09-02 and is currently open access. It has received 1470 citations till now. The article focuses on the topics: Disease burden & Case fatality rate.

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Citations
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Journal ArticleDOI

Molecular characterization of respiratory syncytial virus circulating in Tunisia between 2015 and 2018.

Amira Jerbi, +18 more
- 05 Aug 2020 - 
TL;DR: The data suggest that RSV-A genotype ON1 andRSV-B genotype BA10, both with duplications in the G gene, were widely circulating in the Central coastal region of Tunisia between 2015 and 2018.
Journal ArticleDOI

Biochemical Characterization of Respiratory Syncytial Virus RNA-Dependent RNA Polymerase Complex.

Anand Balakrishnan, +9 more
- 22 Sep 2020 - 
TL;DR: It is determined that the intact L protein is essential for RdRP activity and in truncated L protein constructs Rd RP activity is abrogated due to their deficiency in RNA template binding.
Journal ArticleDOI

Estimates of the national burden of respiratory syncytial virus in Kenyan children aged under 5 years, 2010–2018

Bryan O. Nyawanda, +9 more
- 31 Mar 2023 - 
TL;DR: In this paper , the authors estimated age-specific rates of acute respiratory illness (ARI), severe acute respiratory illnesses (SARI-defined as hospitalization with cough or difficulty breathing with onset within the past 10 days), and SARI-associated deaths.
Journal ArticleDOI

Hyper-Enriched Anti-RSV Immunoglobulins Nasally Administered: A Promising Approach for Respiratory Syncytial Virus Prophylaxis.

Emilie Jacque, +15 more
- 07 Jun 2021 - 
TL;DR: In this paper, a new drug class of immunoglobulins, derived from human non hyper-immune plasma that was generated by an innovative bioprocess, called Ig cracking, combining expertises in plasma-derived products and affinity chromatography.
Journal ArticleDOI

The adaptive immune system in early life: The shift makes it count

Daan K. J. Pieren, +2 more
- 17 Nov 2022 - 
TL;DR: In this article , the authors provide insight into the early life's adaptive immune system by addressing recent literature, and they speculate that this shift from innate-like and tolerogenic adaptive immune features towards formation of immune memory may underlie different efficacy of infant vaccination in these different phases of immune development.
References
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Journal ArticleDOI

Meta-Analysis in Clinical Trials*

Rebecca DerSimonian, +3 more
- 01 Sep 1986 - 
TL;DR: This paper examines eight published reviews each reporting results from several related trials in order to evaluate the efficacy of a certain treatment for a specified medical condition and suggests a simple noniterative procedure for characterizing the distribution of treatment effects in a series of studies.

The Global Burden of Disease Study

Christopher J L Murray, +1 more
Journal ArticleDOI

Global, regional, and national life expectancy, all-cause mortality, and cause-specific mortality for 249 causes of death, 1980–2015: a systematic analysis for the Global Burden of Disease Study 2015

Haidong Wang, +844 more
- 08 Oct 2016 - 
TL;DR: The Global Burden of Disease 2015 Study provides a comprehensive assessment of all-cause and cause-specific mortality for 249 causes in 195 countries and territories from 1980 to 2015, finding several countries in sub-Saharan Africa had very large gains in life expectancy, rebounding from an era of exceedingly high loss of life due to HIV/AIDS.
Journal ArticleDOI

Global, regional, and national causes of child mortality in 2000-13, with projections to inform post-2015 priorities: an updated systematic analysis.

Lei Liu, +8 more
- 31 Jan 2015 - 
TL;DR: The authors' projection results provide concrete examples of how the distribution of child causes of deaths could look in 15-20 years to inform priority setting in the post-2015 era.
Journal ArticleDOI

Global burden of acute lower respiratory infections due to respiratory syncytial virus in young children: a systematic review and meta-analysis

Harish Nair, +24 more
- 01 May 2010 - 
TL;DR: Mortality data suggest that RSV is an important cause of death in childhood from ALRI, after pneumococcal pneumonia and Haemophilus influenzae type b, and the development of novel prevention and treatment strategies should be accelerated as a priority.
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