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Open AccessJournal ArticleDOI

Global, regional, and national disease burden estimates of acute lower respiratory infections due to respiratory syncytial virus in young children in 2015: a systematic review and modelling study

Ting Shi, +138 more
- 02 Sep 2017 - 
- Vol. 390, Iss: 10098, pp 946-958
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TLDR
In this paper, the authors estimated the incidence and hospital admission rate of RSV-associated acute lower respiratory infection (RSV-ALRI) in children younger than 5 years stratified by age and World Bank income regions.
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This article is published in The Lancet.The article was published on 2017-09-02 and is currently open access. It has received 1470 citations till now. The article focuses on the topics: Disease burden & Case fatality rate.

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RSV Epidemiology in Australia Before and During COVID-19.

TL;DR: Observations provide evidence that the shifted 2020 RSV season was no more severe than previous years and increased RSV infections in children aged 2 to 4 years may be explained by a buildup in age-specific population susceptibility and increased testing in older children.
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Structures of respiratory syncytial virus G antigen bound to broadly neutralizing antibodies.

TL;DR: The cocrystal structures of two high-affinity broadly neutralizing human monoclonal antibodies bound to the RSV G CCD are described, providing structural insights into how neutralizing mAbs interact with theRSV G glycoprotein and may advance the development of new RSV vaccines and therapeutics.
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Does respiratory syncytial virus lower respiratory illness in early life cause recurrent wheeze of early childhood and asthma? Critical review of the evidence and guidance for future studies from a World Health Organization-sponsored meeting

TL;DR: The evidence is inconclusive in establishing a causal association between RSV LRTI and RWEC/asthma, the evidence does not establish that RSV mAbs will have a substantial effect on these outcomes and regardless of the association with long-term childhood respiratory morbidity, severe acute RSV disease in young children poses a substantial public health burden.
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Sirtuin 1 regulates mitochondrial function and immune homeostasis in respiratory syncytial virus infected dendritic cells.

TL;DR: Reverse Phase Protein Array functional proteomics analyses of SIRT1-/- and WT BMDC during RSV infection identified a range of differentially regulated proteins involved in pathways that play a critical role in mitochondrial metabolism, autophagy, oxidative and ER stress, and DNA damage.
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The human viral challenge model: accelerating the evaluation of respiratory antivirals, vaccines and novel diagnostics.

TL;DR: The disease burden for acute respiratory viral infections for which current conventional development strategies have failed to produce therapeutics that meet clinical need is described and its utility to assist in the development of novel diagnostics is described.
References
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Journal ArticleDOI

Meta-Analysis in Clinical Trials*

TL;DR: This paper examines eight published reviews each reporting results from several related trials in order to evaluate the efficacy of a certain treatment for a specified medical condition and suggests a simple noniterative procedure for characterizing the distribution of treatment effects in a series of studies.
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Global, regional, and national life expectancy, all-cause mortality, and cause-specific mortality for 249 causes of death, 1980–2015: a systematic analysis for the Global Burden of Disease Study 2015

Haidong Wang, +844 more
- 08 Oct 2016 - 
TL;DR: The Global Burden of Disease 2015 Study provides a comprehensive assessment of all-cause and cause-specific mortality for 249 causes in 195 countries and territories from 1980 to 2015, finding several countries in sub-Saharan Africa had very large gains in life expectancy, rebounding from an era of exceedingly high loss of life due to HIV/AIDS.
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Global, regional, and national causes of child mortality in 2000-13, with projections to inform post-2015 priorities: an updated systematic analysis.

TL;DR: The authors' projection results provide concrete examples of how the distribution of child causes of deaths could look in 15-20 years to inform priority setting in the post-2015 era.
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