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Open AccessJournal ArticleDOI

Global, regional, and national disease burden estimates of acute lower respiratory infections due to respiratory syncytial virus in young children in 2015: a systematic review and modelling study

Ting Shi, +138 more
- 02 Sep 2017 - 
- Vol. 390, Iss: 10098, pp 946-958
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TLDR
In this paper, the authors estimated the incidence and hospital admission rate of RSV-associated acute lower respiratory infection (RSV-ALRI) in children younger than 5 years stratified by age and World Bank income regions.
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This article is published in The Lancet.The article was published on 2017-09-02 and is currently open access. It has received 1470 citations till now. The article focuses on the topics: Disease burden & Case fatality rate.

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Infants Infected with Respiratory Syncytial Virus Generate Potent Neutralizing Antibodies that Lack Somatic Hypermutation

TL;DR: In this article, the authors isolated more than 450 RSV fusion glycoprotein (F)-specific antibodies from 7 RSV-infected infants and found that half of the antibodies recognized only two antigenic sites.
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Respiratory Syncytial Virus Seasonality - United States, 2014-2017.

TL;DR: Across three RSV seasons, lasting from the week ending July 5, 2014 through July 1, 2017, the median RSV onset occurred at week 41 (mid-October), and lasted 31 weeks until week 18 (early May), and the median national peak occurred at weeks 5 (early February), which differed from those reported from previous seasons.
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Past, Present and Future Approaches to the Prevention and Treatment of Respiratory Syncytial Virus Infection in Children

TL;DR: Management of RSV remains centered around prophylaxis with the monoclonal antibody palivizumab, which has proven effective in reducing RSV hospitalization in preterm infants, children with bronchopulmonary dysplasia, and infants with hemodynamically significant congenital heart disease.
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Structure of the Respiratory Syncytial Virus Polymerase Complex

TL;DR: The 3.2-Å cryo-EM structure of RSV L bound to tetrameric P reveals a striking tentacular arrangement of P, with each of the four monomers adopting a distinct conformation, which provides a framework for determining the molecular underpinnings ofRSV replication and transcription and should facilitate the design of effective RSV inhibitors.
References
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Journal ArticleDOI

Meta-Analysis in Clinical Trials*

TL;DR: This paper examines eight published reviews each reporting results from several related trials in order to evaluate the efficacy of a certain treatment for a specified medical condition and suggests a simple noniterative procedure for characterizing the distribution of treatment effects in a series of studies.
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Global, regional, and national life expectancy, all-cause mortality, and cause-specific mortality for 249 causes of death, 1980–2015: a systematic analysis for the Global Burden of Disease Study 2015

Haidong Wang, +844 more
- 08 Oct 2016 - 
TL;DR: The Global Burden of Disease 2015 Study provides a comprehensive assessment of all-cause and cause-specific mortality for 249 causes in 195 countries and territories from 1980 to 2015, finding several countries in sub-Saharan Africa had very large gains in life expectancy, rebounding from an era of exceedingly high loss of life due to HIV/AIDS.
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Global, regional, and national causes of child mortality in 2000-13, with projections to inform post-2015 priorities: an updated systematic analysis.

TL;DR: The authors' projection results provide concrete examples of how the distribution of child causes of deaths could look in 15-20 years to inform priority setting in the post-2015 era.
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