Hierarchical Genetic Organization of Human Cortical Surface Area
Chi-Hua Chen,E. D. Gutiérrez,Thompson Wk,Matthew S. Panizzon,Terry L. Jernigan,Lisa T. Eyler,Lisa T. Eyler,Christine Fennema-Notestine,Amy J. Jak,Michael C. Neale,Carol E. Franz,Michael J. Lyons,Michael D. Grant,Bruce Fischl,Larry J. Seidman,Ming T. Tsuang,Ming T. Tsuang,William S. Kremen,William S. Kremen,Anders M. Dale +19 more
TLDR
Using a data-driven, fuzzy clustering technique with magnetic resonance imaging data from 406 twins, this work parceled cortical surface area into genetic subdivisions, creating a human brain atlas based solely on genetically informative data.Abstract:
Surface area of the cerebral cortex is a highly heritable trait, yet little is known about genetic influences on regional cortical differentiation in humans. Using a data-driven, fuzzy clustering technique with magnetic resonance imaging data from 406 twins, we parceled cortical surface area into genetic subdivisions, creating a human brain atlas based solely on genetically informative data. Boundaries of the genetic divisions corresponded largely to meaningful structural and functional regions; however, the divisions represented previously undescribed phenotypes different from conventional (non-genetically based) parcellation systems. The genetic organization of cortical area was hierarchical, modular, and predominantly bilaterally symmetric across hemispheres. We also found that the results were consistent with human-specific regions being subdivisions of previously described, genetically based lobar regionalization patterns.read more
Citations
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疟原虫var基因转换速率变化导致抗原变异[英]／Paul H, Robert P, Christodoulou Z, et al//Proc Natl Acad Sci U S A
TL;DR: PfPMP1）与感染红细胞、树突状组胞以及胎盘的单个或多个受体作用，在黏附及免疫逃避中起关键的作�ly.
Journal ArticleDOI
Imaging structural co-variance between human brain regions.
TL;DR: The state of current research into brain structural co-variance, its underlying mechanisms and its potential value in the understanding of various neurological and psychiatric conditions are discussed.
Journal ArticleDOI
The ENIGMA Consortium: large-scale collaborative analyses of neuroimaging and genetic data
Paul M. Thompson,Jason L. Stein,Sarah E. Medland,Derrek P. Hibar,Alejandro Arias Vasquez,Miguel E. Rentería,Roberto Toro,Neda Jahanshad,Gunter Schumann,Barbara Franke,Margaret J. Wright,Nicholas G. Martin,Ingrid Agartz,Ingrid Agartz,Martin Alda,Saud Alhusaini,Saud Alhusaini,Laura Almasy,Jorge R. C. Almeida,Jorge R. C. Almeida,Jorge R. C. Almeida,Kathryn I. Alpert,Nancy C. Andreasen,Ole A. Andreassen,Liana G. Apostolova,Katja Appel,Nicola J. Armstrong,Benjamin S. Aribisala,Mark E. Bastin,Michael Bauer,Carrie E. Bearden,Ørjan Bergmann,Elisabeth B. Binder,John Blangero,HJ Bockholt,Erlend Bøen,Catherine Bois,Dorret I. Boomsma,Tom Booth,Ian Bowman,Janita Bralten,Rachel M. Brouwer,Han G. Brunner,David G. Brohawn,Randy L. Buckner,Jan K. Buitelaar,Kazima B. Bulayeva,Juan R. Bustillo,Vince D. Calhoun,Vince D. Calhoun,Dara M. Cannon,Rita M. Cantor,Melanie A. Carless,Xavier Caseras,Gianpiero L. Cavalleri,M. Mallar Chakravarty,Kiki D. Chang,Christopher R.K. Ching,Andrea Christoforou,Andrea Christoforou,Sven Cichon,Sven Cichon,Vincent P. Clark,Patricia J. Conrod,Patricia J. Conrod,Giovanni Coppola,Benedicto Crespo-Facorro,Joanne E. Curran,Michael Czisch,Ian J. Deary,Eco J. C. de Geus,Anouk den Braber,G. Delvecchio,Chantal Depondt,Lieuwe de Haan,Lieuwe de Haan,Greig I. de Zubicaray,Danai Dima,Rali Dimitrova,Srdjan Djurovic,Hong-Wei Dong,Gary Donohoe,Gary Donohoe,Ravindranath Duggirala,Thomas D. Dyer,Stefan Ehrlich,Stefan Ehrlich,Carl Johan Ekman,Torbjørn Elvsåshagen,Louise Emsell,Susanne Erk,Thomas Espeseth,Jesen Fagerness,Scott C. Fears,Iryna O. Fedko,Guillén Fernández,Simon E. Fisher,Simon E. Fisher,Tatiana Foroud,Peter T. Fox,Clyde Francks,Clyde Francks,Sophia Frangou,Eva Maria Frey,Thomas Frodl,Thomas Frodl,Vincent Frouin,Hugh Garavan,Sudheer Giddaluru,David C. Glahn,Beata R. Godlewska,Rita Z. Goldstein,Randy L. Gollub,Hans J. Grabe,Oliver Grimm,Oliver Gruber,Tulio Guadalupe,Raquel E. Gur,Ruben C. Gur,Ruben C. Gur,Harald H H Göring,Saskia P. Hagenaars,Tomas Hajek,Geoffrey B. Hall,Jeremy Hall,Jeremy Hall,John Hardy,Catharina A. Hartman,Johanna Hass,Sean N. Hatton,Unn K. Haukvik,K Hegenscheid,Andreas Heinz,Ian B. Hickie,Beng-Choon Ho,D. Hoehn,Pieter J. Hoekstra,Marisa O. Hollinshead,Avram J. Holmes,Georg Homuth,Martine Hoogman,L. Elliot Hong,Norbert Hosten,Jouke-Jan Hottenga,Hilleke E. Hulshoff Pol,Kristy S. Hwang,Clifford R. Jack,Mark Jenkinson,Caroline Johnston,Caroline Johnston,Erik G. Jönsson,René S. Kahn,Dalia Kasperaviciute,Sinead Kelly,Sungeun Kim,Peter Kochunov,Laura Koenders,Laura Koenders,Bernd Krämer,John B.J. Kwok,John B.J. Kwok,Jim Lagopoulos,Gonzalo Laje,Mikael Landén,Mikael Landén,Bennett A. Landman,John Lauriello,Stephen M. Lawrie,Phil Lee,Phil Lee,Stephanie Le Hellard,Stephanie Le Hellard,Herve Lemaitre,Cassandra D. Leonardo,Chiang shan Li,Benny Liberg,David C. Liewald,Xinmin Liu,Xinmin Liu,Lorna M. Lopez,Eva Loth,Anbarasu Lourdusamy,Michelle Luciano,Fabio Macciardi,Fabio Macciardi,Marise W. J. Machielsen,Marise W. J. Machielsen,Glenda MacQueen,Ulrik Fredrik Malt,René C.W. Mandl,Dara S. Manoach,Jean-Luc Martinot,Mar Matarin,Karen A. Mather,Manuel Mattheisen,Manuel Mattheisen,Morten Mattingsdal,Andreas Meyer-Lindenberg,Colm McDonald,Andrew M. McIntosh,Francis J. McMahon,Katie L. McMahon,Eva M. Meisenzahl,Ingrid Melle,Yuri Milaneschi,Yuri Milaneschi,Sebastian Mohnke,Grant W. Montgomery,Derek W. Morris,Eric K. Moses,Eric K. Moses,Bryon A. Mueller,Susana Muñoz Maniega,Thomas W. Mühleisen,Bertram Müller-Myhsok,Benson Mwangi,Matthias Nauck,Kwangsik Nho,Thomas E. Nichols,Lars-Göran Nilsson,Lars-Göran Nilsson,Allison C. Nugent,Lars Nyberg,Rene L. Olvera,Jaap Oosterlaan,Roel A. Ophoff,Roel A. Ophoff,Massimo Pandolfo,Melina Papalampropoulou-Tsiridou,Martina Papmeyer,Tomáš Paus,Zdenka Pausova,Godfrey D. Pearlson,Godfrey D. Pearlson,Brenda W.J.H. Penninx,Charles P. Peterson,Andrea Pfennig,Mary L. Phillips,G. Bruce Pike,Jean-Baptiste Poline,Steven G. Potkin,Benno Pütz,Adaikalavan Ramasamy,Adaikalavan Ramasamy,Jerod M. Rasmussen,Marcella Rietschel,Mark Rijpkema,Shannon L. Risacher,Joshua L. Roffman,Roberto Roiz-Santiañez,Nina Romanczuk-Seiferth,Emma J. Rose,Natalie A. Royle,Dan Rujescu,Mina Ryten,Mina Ryten,Perminder S. Sachdev,Alireza Salami,Alireza Salami,Theodore D. Satterthwaite,Jonathan Savitz,Jonathan Savitz,Andrew J. Saykin,Cathy Scanlon,Lianne Schmaal,Hugo G. Schnack,Andrew J. Schork,S. Charles Schulz,Remmelt R. Schür,Larry J. Seidman,Li Shen,Jody M. Shoemaker,Andrew Simmons,Andrew Simmons,Sanjay M. Sisodiya,Colin Smith,Jordan W. Smoller,Jordan W. Smoller,Jair C. Soares,Scott R. Sponheim,Scott R. Sponheim,Emma Sprooten,John M. Starr,Vidar M. Steen,Vidar M. Steen,Stephen M. Strakowski,Lachlan T. Strike,Jessika E. Sussmann,Philipp G. Sämann,Alexander Teumer,Arthur W. Toga,Diana Tordesillas-Gutiérrez,Daniah Trabzuni,Daniah Trabzuni,Sarah Trost,Jessica A. Turner,Jessica A. Turner,Martijn P. van den Heuvel,Nic J.A. van der Wee,Kristel R. van Eijk,Theo G.M. van Erp,Neeltje E.M. van Haren,Dennis van 't Ent,Marie-José van Tol,Maria C. Valdés Hernández,Dick J. Veltman,Amelia Versace,Henry Völzke,Robert Walker,Henrik Walter,Henrik Walter,Lei Wang,Joanna M. Wardlaw,Michael E. Weale,Michael W. Weiner,Wei Wen,Lars T. Westlye,Heather C. Whalley,Christopher D. Whelan,Tonya White,Anderson M. Winkler,Anderson M. Winkler,Katharina Wittfeld,Girma Woldehawariat,Christiane Wolf,David Zilles,Marcel P. Zwiers,Anbupalam Thalamuthu,Peter R. Schofield,Peter R. Schofield,Nelson B. Freimer,Natalia Lawrence,Wayne C. Drevets +332 more
TL;DR: The ENIGMA Consortium has detected factors that affect the brain that no individual site could detect on its own, and that require larger numbers of subjects than any individual neuroimaging study has currently collected.
Journal ArticleDOI
Probabilistic Maps of Visual Topography in Human Cortex
TL;DR: Overall, the probabilistic atlases quantify the variability of topographic representations in human cortex and provide a useful reference for comparing data across studies that can be transformed into these standard spaces.
Journal ArticleDOI
The modular and integrative functional architecture of the human brain.
TL;DR: A network account of the brain’s modular yet integrated implementation of cognitive functions is provided and a strong spatial correspondence between the cognitive functions and the network”s modules is found, suggesting that each module performs a discrete cognitive function.
References
More filters
疟原虫var基因转换速率变化导致抗原变异[英]／Paul H, Robert P, Christodoulou Z, et al//Proc Natl Acad Sci U S A
TL;DR: PfPMP1）与感染红细胞、树突状组胞以及胎盘的单个或多个受体作用，在黏附及免疫逃避中起关键的作�ly.
Book
Finding Groups in Data: An Introduction to Cluster Analysis
TL;DR: An electrical signal transmission system, applicable to the transmission of signals from trackside hot box detector equipment for railroad locomotives and rolling stock, wherein a basic pulse train is transmitted whereof the pulses are of a selected first amplitude and represent a train axle count.
Journal ArticleDOI
Cortical surface-based analysis. I. Segmentation and surface reconstruction
TL;DR: A set of automated procedures for obtaining accurate reconstructions of the cortical surface are described, which have been applied to data from more than 100 subjects, requiring little or no manual intervention.
BookDOI
Finding Groups in Data
TL;DR: In this article, an electrical signal transmission system for railway locomotives and rolling stock is proposed, where a basic pulse train is transmitted whereof the pulses are of a selected first amplitude and represent a train axle count, and a spike pulse of greater selected amplitude is transmitted, occurring immediately after the axle count pulse to which it relates, whenever an overheated axle box is detected.
Journal ArticleDOI
Finding Groups in Data: An Introduction to Chster Analysis
TL;DR: This book make understandable the cluster analysis is based notion of starsmodern treatment, which efficiently finds accurate clusters in data and discusses various types of study the user set explicitly but also proposes another.