How do lncRNAs regulate transcription
TLDR
Recent progress in elucidating the molecular mechanisms by which lncRNAs modulate gene expression is reviewed, including the act of lnc RNA transcription rather than the lncRNA product that appears to be regulatory.Abstract:
It has recently become apparent that RNA, itself the product of transcription, is a major regulator of the transcriptional process. In particular, long noncoding RNAs (lncRNAs), which are so numerous in eukaryotes, function in many cases as transcriptional regulators. These RNAs function through binding to histone-modifying complexes, to DNA binding proteins (including transcription factors), and even to RNA polymerase II. In other cases, it is the act of lncRNA transcription rather than the lncRNA product that appears to be regulatory. We review recent progress in elucidating the molecular mechanisms by which lncRNAs modulate gene expression and future opportunities in this research field.read more
Citations
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Regulation of histone methylation by automethylation of PRC2
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Long non-coding RNA-polycomb intimate rendezvous.
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Role of lncRNAs in cis- and trans-regulatory responses to salt in Populus trichocarpa.
Xiaoxue Ye,Shuo Wang,Xijuan Zhao,Ni Gao,Yao Wang,Yanmei Yang,Ernest Wu,Cheng Jiang,Yuxiang Cheng,Wenwu Wu,Shenkui Liu +10 more
TL;DR: The results shed light on lncRNAs cis- and trans-regulating gene expression in Populus and provide an example of long-term salt-induced Ptlinc-NAC72 that could be used to mitigate growth costs with plant resilience to salt stress.
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LncRNA MIR4435-2HG mediates cisplatin resistance in HCT116 cells by regulating Nrf2 and HO-1.
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TL;DR: It is demonstrated that the lncRNA MIR4435-2HG is a main factor driving the cisplatin resistance of HCT116 cells, and Nrf2 and HO-1 mRNA levels, as critical molecules in the oxidative stress pathway, were inhibited by siRNAs targeting MIR 4435-1.
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