How do lncRNAs regulate transcription
TLDR
Recent progress in elucidating the molecular mechanisms by which lncRNAs modulate gene expression is reviewed, including the act of lnc RNA transcription rather than the lncRNA product that appears to be regulatory.Abstract:
It has recently become apparent that RNA, itself the product of transcription, is a major regulator of the transcriptional process. In particular, long noncoding RNAs (lncRNAs), which are so numerous in eukaryotes, function in many cases as transcriptional regulators. These RNAs function through binding to histone-modifying complexes, to DNA binding proteins (including transcription factors), and even to RNA polymerase II. In other cases, it is the act of lncRNA transcription rather than the lncRNA product that appears to be regulatory. We review recent progress in elucidating the molecular mechanisms by which lncRNAs modulate gene expression and future opportunities in this research field.read more
Citations
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Journal ArticleDOI
Functions of DEAD box RNA helicases DDX5 and DDX17 in chromatin organization and transcriptional regulation.
TL;DR: This review will comprehensively describe the current knowledge on different mechanisms of DDX5 and DDX17's function as coregulators of transcription factors and how these could impact gene expression at the transcriptional and post-transcriptional levels.
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Processing and roles of snoRNA-ended long noncoding RNAs
Yu-Hang Xing,Ling-Ling Chen +1 more
TL;DR: A mini-review is provided to discuss the biogenesis and functions of some sno-lncRNAs and SPAs involved in the regulation of pre-rRNA transcription and alternative splicing ofPre-mRNAs.
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Targeting the Oncogenic Long Non-coding RNA SLNCR1 by Blocking Its Sequence-Specific Binding to the Androgen Receptor
Karyn Schmidt,Chase A. Weidmann,Thomas A. Hilimire,Elaine Yee,Elaine Yee,Breanne M. Hatfield,John S. Schneekloth,Kevin M. Weeks,Carl D. Novina,Carl D. Novina +9 more
TL;DR: Delivery of oligos that block SLNCR1-AR interaction thus represent a plausible therapeutic strategy and are predictive of AR binding, as an AR-binding motif is identified in lncRNA HOXA11-AS-203.
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Long noncoding RNA functionality in imprinted domain regulation.
TL;DR: The multiple functionalities attributed to lncRNAs and how they regulate imprinted gene expression are discussed and unresolved questions about imprinted lncRNA function are raised, which may lead to new avenues of investigation.
Journal ArticleDOI
BC200 (BCYRN1) - The shortest, long, non-coding RNA associated with cancer.
TL;DR: What is known about BC200 is summarized, primarily from studies in neuronal systems, before turning to a review of recent work that aims to understand how this lncRNA contributes to cancer initiation, progression and metastasis, along with its possible clinical utility as a biomarker or therapeutic target.
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