How do lncRNAs regulate transcription
TLDR
Recent progress in elucidating the molecular mechanisms by which lncRNAs modulate gene expression is reviewed, including the act of lnc RNA transcription rather than the lncRNA product that appears to be regulatory.Abstract:
It has recently become apparent that RNA, itself the product of transcription, is a major regulator of the transcriptional process. In particular, long noncoding RNAs (lncRNAs), which are so numerous in eukaryotes, function in many cases as transcriptional regulators. These RNAs function through binding to histone-modifying complexes, to DNA binding proteins (including transcription factors), and even to RNA polymerase II. In other cases, it is the act of lncRNA transcription rather than the lncRNA product that appears to be regulatory. We review recent progress in elucidating the molecular mechanisms by which lncRNAs modulate gene expression and future opportunities in this research field.read more
Citations
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RNA delivery by extracellular vesicles in mammalian cells and its applications.
Killian P. O’Brien,Koen Breyne,Stefano Ughetto,Stefano Ughetto,Louise C. Laurent,Xandra O. Breakefield +5 more
TL;DR: This Review focuses on the current state of knowledge pertaining to packaging, transport and function of RNAs in extracellular vesicles and outlines the progress made thus far towards their clinical applications.
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Long Non-Coding RNAs in the Regulation of Gene Expression: Physiology and Disease
Juliane Cristina Ribeiro Fernandes,Stephanie Maia Acuña,Juliana Ide Aoki,Lucile Maria Floeter-Winter,Sandra Marcia Muxel +4 more
TL;DR: Key aspects of lncRNA biology are reviewed, focusing on their role as regulatory elements in gene expression modulation during physiological and disease processes, with implications in host and pathogens physiology, and their role in immune response modulation.
Journal ArticleDOI
Non-Coding RNAs and their Integrated Networks.
TL;DR: This review discusses the distinct types of ncRNAs, including housekeeping n cRNAs and regulatory nc RNAs, their versatile functions and interactions, transcription, translation, and modification, and summarizes the integrated networks of n cRNA interactions, providing a comprehensive landscape of nCRNAs regulatory roles.
Journal ArticleDOI
Long non-coding RNA: Classification, biogenesis and functions in blood cells.
Swati Dahariya,Indira Paddibhatla,Santosh Kumar,Sanjeev Raghuwanshi,Adithya Pallepati,Ravi Kumar Gutti +5 more
TL;DR: The current status of knowledge on lncRNAs classification, biogenesis and its role in blood cells is summarized.
Journal ArticleDOI
Emerging roles of lncRNAs in the post-transcriptional regulation in cancer.
TL;DR: In this paper, the authors discuss latest developments in lncRNA-meditated gene expression at the post-transcriptional level, including gene splicing, mRNA stability, protein stability and nuclear trafficking.
References
More filters
Journal ArticleDOI
Equality for X Chromosomes
TL;DR: A subtle alteration of chromatin structure may impose this modest, but vital adjustment of the X chromosome transcription level in the Drosophila melanogaster and Caenorhabditis elegans systems.
ATRX Directs Binding of PRC2 to Xist RNA and Polycomb Targets
Kavitha Sarma,Kavitha Sarma,Catherine Cifuentes-Rojas,Catherine Cifuentes-Rojas,Ayla Ergun,Amanda M. Del Rosario,Yesu Jeon,Yesu Jeon,Forest M. White,Ruslan I. Sadreyev,Jeannie T. Lee +10 more
TL;DR: In this paper, an unbiased proteomics approach was applied to isolate Xist and PRC2 regulators and identified ATRX, which is a required specificity determinant for Xist/PRC2 targeting and function.
Journal ArticleDOI
TERRA and the state of the telomere
Karsten Rippe,Brian Luke +1 more
TL;DR: It is proposed that TERRA orchestrates different activities at chromosome ends in a manner that depends on the state of the telomere.
Journal ArticleDOI
Nucleic acid-binding specificity of human FUS protein
TL;DR: It is concluded that FUS has quite general nucleic acid-binding activity, with the various proposed RNA motifs being neither necessary for FUS binding nor sufficient to explain its diverse binding partners.
Journal ArticleDOI
Regulated transcription of the genes for actin and heat-shock proteins in culture drosophila cells
RC Findly,T Pederson +1 more
TL;DR: The rapidity, magnitude, and reversibility of the shifts in actin and heat-shock gene transcription constitute compelling advantages for the use of cultured drosophila cells in studying the transcriptional regulation of eukaryotic genes, including one related to the cytoskeleton.
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