How do lncRNAs regulate transcription
TLDR
Recent progress in elucidating the molecular mechanisms by which lncRNAs modulate gene expression is reviewed, including the act of lnc RNA transcription rather than the lncRNA product that appears to be regulatory.Abstract:
It has recently become apparent that RNA, itself the product of transcription, is a major regulator of the transcriptional process. In particular, long noncoding RNAs (lncRNAs), which are so numerous in eukaryotes, function in many cases as transcriptional regulators. These RNAs function through binding to histone-modifying complexes, to DNA binding proteins (including transcription factors), and even to RNA polymerase II. In other cases, it is the act of lncRNA transcription rather than the lncRNA product that appears to be regulatory. We review recent progress in elucidating the molecular mechanisms by which lncRNAs modulate gene expression and future opportunities in this research field.read more
Citations
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The potential of glutamine metabolism-related long non-coding RNAs (lncRNAs) as prognostic biomarkers in multiple myeloma patients
Yun Zhong,Shenghua Xu,Zhe Liu +2 more
TL;DR: In this paper , the role of Gln-associated lncRNAs in Gln metabolism contributing for tumor-related pathways and immune microenvironment in multiple myeloma (MM) patients was investigated.
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Transcription factors interact with RNA to regulate genes
TL;DR: This paper found that at least half of TFs also bind RNA, doing so through a previously unrecognized domain with sequence and functional features analogous to the arginine-rich motif of the HIV transcriptional activator Tat.
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FAR591 promotes the pathogenesis and progression of SONFH by regulating Fos expression to mediate the apoptosis of bone microvascular endothelial cells
Fei Zhang,Lei Wei,Lei Wang,Tao Wang,Zhihong Xie,Hong Luo,Fa-peng Li,Jianli Zhang,Wentao Dong,Gang Liu,Qinglin Kang,Xuesong Zhu,Wuxun Peng +12 more
TL;DR: In this paper , the role and mechanism of long noncoding RNAs (lncRNAs) in the pathogenesis of osteonecrosis of the femoral head (SONFH) were investigated.
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LINC00586 Represses ASXL1 Expression Thus Inducing Epithelial-To-Mesenchymal Transition of Colorectal Cancer Cells Through LSD1-Mediated H3K4me2 Demethylation
TL;DR: Overall, discovery of the LINC00586/LSD1/ASXL1 axis partially explains epigenetic mechanism regulating EMT in CRC, providing a therapeutic target to limit CRC metastasis.
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Long Noncoding RNAs as Orchestrators of CD4+ T-Cell Fate
TL;DR: Aiming at elucidating how lncRNAs modulate CD4+ T-cell differentiation in disparate immune diseases may provide a basis for the pathological mechanism of immune-mediated diseases.
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