How do lncRNAs regulate transcription
TLDR
Recent progress in elucidating the molecular mechanisms by which lncRNAs modulate gene expression is reviewed, including the act of lnc RNA transcription rather than the lncRNA product that appears to be regulatory.Abstract:
It has recently become apparent that RNA, itself the product of transcription, is a major regulator of the transcriptional process. In particular, long noncoding RNAs (lncRNAs), which are so numerous in eukaryotes, function in many cases as transcriptional regulators. These RNAs function through binding to histone-modifying complexes, to DNA binding proteins (including transcription factors), and even to RNA polymerase II. In other cases, it is the act of lncRNA transcription rather than the lncRNA product that appears to be regulatory. We review recent progress in elucidating the molecular mechanisms by which lncRNAs modulate gene expression and future opportunities in this research field.read more
Citations
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Long Non-Coding RNA Associated with Cholesterol Homeostasis and Its Involvement in Metabolic Diseases.
TL;DR: The role of lncRNAs is organized according to the major issues in cholesterol homeostasis: efflux, metabolism and synthesis, and disease process.
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Practical guide for circular RNA analysis: Steps, tips, and resources
TL;DR: In this paper, the authors provide guidelines to consider when developing studies on circRNAs, including detecting and selecting the circRNA, identifying their binding partners and sites of interaction, modulating circRNA levels, assessing copy numbers and stoichiometry, and addressing other points unique to circRNA analysis.
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LINC00978 promotes hepatocellular carcinoma carcinogenesis partly via activating the MAPK/ERK pathway
TL;DR: LINC00978 is highly expressed in human HCC tissue and correlates with poor HCC prognosis, partially by activating the MAPK/ERK pathway and promotes HCC cell proliferation, cell cycle progression, and survival.
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Transcription factors interact with RNA to regulate genes
Ozgur Oksuz,Jonathan E. Henninger,Robert Warneford-Thomson,Ming M. Zheng,Hailey Erb,Kalon J. Overholt,Susana Wilson Hawken,Salman F. Banani,Rich Lauman,Adrienne Vancura,Anne L. Robertson,Nancy M. Hannett,Tong Ihn Lee,Leonard I. Zon,Roberto Bonasio,Richard A. Young +15 more
TL;DR: It is proposed that the ability to bind DNA, RNA and protein is a general property of many TFs and is fundamental to their gene regulatory function.
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Identification of key lncRNAs in the carcinogenesis and progression of colon adenocarcinoma by co-expression network analysis.
TL;DR: Through co‐expression analysis, four key lncRNAs in association with the carcinogenesis and progression of COAD might have important clinical implications for improving the risk stratification, therapeutic decision and prognosis prediction in COAD patients.
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