How do lncRNAs regulate transcription
TLDR
Recent progress in elucidating the molecular mechanisms by which lncRNAs modulate gene expression is reviewed, including the act of lnc RNA transcription rather than the lncRNA product that appears to be regulatory.Abstract:
It has recently become apparent that RNA, itself the product of transcription, is a major regulator of the transcriptional process. In particular, long noncoding RNAs (lncRNAs), which are so numerous in eukaryotes, function in many cases as transcriptional regulators. These RNAs function through binding to histone-modifying complexes, to DNA binding proteins (including transcription factors), and even to RNA polymerase II. In other cases, it is the act of lncRNA transcription rather than the lncRNA product that appears to be regulatory. We review recent progress in elucidating the molecular mechanisms by which lncRNAs modulate gene expression and future opportunities in this research field.read more
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Genome-wide analysis and functional annotation of chromatin-enriched noncoding RNAs in rice during somatic cell regeneration
Yu-Chan Zhang,Yan-Fei Zhou,Yu Cheng,Jian-Ping Lian,Lu Yang,Rui-Rui He,Mengqi Lei,Yu-Wei Liu,Chao Yuan,Wenquan Zhao,Shi Xiao,Yuemeng Chen +11 more
TL;DR: CheRNAs are a distinct subclass of regulatory non-coding RNAs that are required for somatic cell regeneration and regulate rice traits as mentioned in this paper , which has great potential for crop trait improvement and breeding in future.
Journal ArticleDOI
Genome-wide analysis and functional prediction of the estrogen-regulated transcriptional response in the mouse uterus
Yasmin M. Vasquez,Tulip Nandu,Andrew M. Kelleher,Enrique I Ramos,Shrikanth S. Gadad,Shrikanth S. Gadad,W. Lee Kraus +6 more
TL;DR: A genomic approach for identifying E2-regulated lncRNAs that may serve critical function in the uterus is described and new insights are provided into the understanding of the regulation of hormone-regulated transcriptional responses with implications in pregnancy and endometrial pathologies.
Journal ArticleDOI
Molecular Mechanisms of lncRNAs in the Dependent Regulation of Cancer and Their Potential Therapeutic Use
Carlos García-Padilla,Angel Dueñas,Virginio Garcia-Lopez,Amelia Aránega,Diego Franco,Virginio Garcia-Martinez,Carmen Lopez-Sanchez +6 more
TL;DR: Deregulation of the expression of many lncRNAs in samples, tissues or patients has been pointed out as a molecular regulator in carcinogenesis, with them acting as oncogenes or tumor suppressing genes.
Journal ArticleDOI
Long non-coding RNAs in liver diseases: Focusing on nonalcoholic fatty liver disease, alcohol-related liver disease, and cholestatic liver disease
Sen Han,Ting Zhang,Praveen Kusumanchi,Nazmul Huda,Yanchao Jiang,Zhihong Yang,Suthat Liangpunsakul +6 more
TL;DR: The current knowledge of lncRNAs and their implications in the pathogenesis of three common liver diseases are summarized and improved understanding will provide a useful perspective leading to mechanism-based intervention by targeting specific lnc RNAs for the treatment of liver diseases.
Journal ArticleDOI
Plant epigenomics for extenuation of abiotic stresses: challenges and future perspectives.
Dharmendra Singh,Priya Chaudhary,Jyoti Taunk,Chandan Kumar Singh,S. R. Sharma,Vikram Jeet Singh,Deepti Singh,Viswanathan Chinnusamy,Rajbir Yadav,Madan Pal +9 more
TL;DR: In this paper, a review of epigenome editing in plants is presented, which aims to enhance understanding of stress-induced epigenetic changes in plants and its prospects for development of climate-ready crops.
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