How do lncRNAs regulate transcription
TLDR
Recent progress in elucidating the molecular mechanisms by which lncRNAs modulate gene expression is reviewed, including the act of lnc RNA transcription rather than the lncRNA product that appears to be regulatory.Abstract:
It has recently become apparent that RNA, itself the product of transcription, is a major regulator of the transcriptional process. In particular, long noncoding RNAs (lncRNAs), which are so numerous in eukaryotes, function in many cases as transcriptional regulators. These RNAs function through binding to histone-modifying complexes, to DNA binding proteins (including transcription factors), and even to RNA polymerase II. In other cases, it is the act of lncRNA transcription rather than the lncRNA product that appears to be regulatory. We review recent progress in elucidating the molecular mechanisms by which lncRNAs modulate gene expression and future opportunities in this research field.read more
Citations
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The role of long noncoding RNAs in cancer metastasis
Christine Parsons,Alexis M. Tayoun,Benjamin D. Benado,Gabriel Ragusa,Rose F. Dorvil,Elizabeth A. Rourke,Kaitlyn O’ Connor,Irene K. Guttilla Reed,Angela Alexander,Lian Willetts,Maryam Habibian,Brian D. Adams +11 more
TL;DR: In this review, this review highlights the specific role lncRNAs have in promoting the metastatic cascade across a number of epithelial cancer models.
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FOXO3-induced lncRNA LOC554202 contributes to hepatocellular carcinoma progression via the miR-485-5p/BSG axis.
TL;DR: In this article, the expression and function of long non-coding RNAs (LncRNAs) have played very important roles in malignancy behaviors of hepatocellular carcinoma.
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The nuclear functions of long noncoding RNAs come into focus.
TL;DR: Long noncoding RNAs (lncRNAs) are common outputs of the eukaryotic genome as discussed by the authors, defined as untranslated and tightly-regulated transcripts with a length exceeding 200nt.
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From "Dark Matter" to "Star": Insight Into the Regulation Mechanisms of Plant Functional Long Non-Coding RNAs.
TL;DR: In this paper, the authors provided an overview of the molecular mechanisms of long non-coding RNAs in interacting with other biomolecules with an emphasis on those lncRNAs validated only by low-throughput experiments.
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Extracellular Vesicles and Pancreatic Cancer: Insights on the Roles of miRNA, lncRNA, and Protein Cargos in Cancer Progression.
Roberta Romano,Anna Picca,Anna Picca,Leonardo Henry Eusebi,Emanuele Marzetti,Emanuele Marzetti,Riccardo Calvani,Riccardo Calvani,Loredana Moro,Loredana Moro,Cecilia Bucci,Flora Guerra +11 more
TL;DR: In this paper, the principal cargos of extracellular vesicles characterized in pancreatic precancerous conditions, such as miRNAs, lncRNAs and several proteins, are summarized and discussed.
References
More filters
Journal ArticleDOI
Repurposing CRISPR as an RNA-guided platform for sequence-specific control of gene expression.
Lei S. Qi,Matthew H. Larson,Luke A. Gilbert,Jennifer A. Doudna,Jonathan S. Weissman,Adam P. Arkin,Adam P. Arkin,Wendell A. Lim +7 more
TL;DR: This RNA-guided DNA recognition platform provides a simple approach for selectively perturbing gene expression on a genome-wide scale and can efficiently repress expression of targeted genes in Escherichia coli, with no detectable off-target effects.
Journal ArticleDOI
Long Noncoding RNA as Modular Scaffold of Histone Modification Complexes
Miao-Chih Tsai,Ohad Manor,Yue Wan,Nima Mosammaparast,Jordon K. Wang,Fei Lan,Yang Shi,Eran Segal,Howard Y. Chang +8 more
TL;DR: The results suggest that lincRNAs may serve as scaffolds by providing binding surfaces to assemble select histone modification enzymes, thereby specifying the pattern of histone modifications on target genes.
Journal ArticleDOI
The noncoding RNA revolution-trashing old rules to forge new ones.
TL;DR: The pathway of ncRNA research is described, where every established "rule" seems destined to be overturned.
Journal ArticleDOI
The CBP co-activator is a histone acetyltransferase
TL;DR: It is shown that CBP has intrinsic HAT activity, and Targeting CBP-associated H AT activity to specific promoters may be a mechanism by which E1A acts as a transcriptional activator.
Journal ArticleDOI
A long noncoding RNA maintains active chromatin to coordinate homeotic gene expression
Kevin C. Wang,Yul W. Yang,Bo Liu,Amartya Sanyal,Ryan Corces-Zimmerman,Yong Chen,Bryan R. Lajoie,Angeline Protacio,Ryan A. Flynn,Rajnish A. Gupta,Joanna Wysocka,Ming Lei,Job Dekker,Jill A. Helms,Howard Y. Chang +14 more
TL;DR: OTTIP RNA binds the adaptor protein WDR5 directly and targets WDR 5/MLL complexes across HOXA, driving histone H3 lysine 4 trimethylation and gene transcription.
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