How do lncRNAs regulate transcription
TLDR
Recent progress in elucidating the molecular mechanisms by which lncRNAs modulate gene expression is reviewed, including the act of lnc RNA transcription rather than the lncRNA product that appears to be regulatory.Abstract:
It has recently become apparent that RNA, itself the product of transcription, is a major regulator of the transcriptional process. In particular, long noncoding RNAs (lncRNAs), which are so numerous in eukaryotes, function in many cases as transcriptional regulators. These RNAs function through binding to histone-modifying complexes, to DNA binding proteins (including transcription factors), and even to RNA polymerase II. In other cases, it is the act of lncRNA transcription rather than the lncRNA product that appears to be regulatory. We review recent progress in elucidating the molecular mechanisms by which lncRNAs modulate gene expression and future opportunities in this research field.read more
Citations
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Expression Signature of lncRNAs and mRNAs in Sevoflurane-Induced Mouse Brain Injury: Implication of Involvement of Wide Molecular Networks and Pathways.
TL;DR: Sevoflurane, one of the most commonly used pediatric anesthetics, was found to cause developmental neurotoxicity to understand specific risk groups and develop countermeasures, a better understanding of its mechanisms is needed.
Journal ArticleDOI
lncRNA RBM5-AS1 promotes cell proliferation and invasion by epigenetically silencing miR-132/212 in hepatocellular carcinoma cells.
TL;DR: In this article, the authors demonstrated that RBM5-AS1 acts as an epigenetic regulator to promote the hepatocellular carcinoma (HCC) progression by repressing miR-132/212 expressions.
Journal ArticleDOI
The Emerging Role of Long Non-Coding RNAs in Development and Function of Gilthead Sea Bream (Sparus aurata) Fast Skeletal Muscle
Isabel Garcia-Perez,Anna Molsosa-Solanas,Miquel Perelló-Amorós,Elena Sarropoulou,Josefina Blasco,Joaquim Gutiérrez,D. Garcia de la serrana +6 more
TL;DR: This study represents the first characterization of lncRNAs in gilthead sea bream fast skeletal muscle and provides evidence regarding their involvement in muscle development.
Journal ArticleDOI
Role of Non-coding RNAs in Fungal Pathogenesis and Antifungal Drug Responses
TL;DR: Advances in genomic technologies will help identify the ncRNA repertoire in fungal pathogens, and functional studies will elucidate their mechanisms, which will advance the understanding of host-fungal interactions and potentially help develop better treatment strategies.
Journal ArticleDOI
LncRNA 122049 suppresses apoptosis of renal tubular epithelial cells in ischemic AKI by targeting the miR‐330‐5p/ELK1 axis
TL;DR: It is demonstrated that LncRNA 122049 prevented the I/R‐induced renal cell apoptosis via regulation of the miR‐330‐5p/ELK1 axis, which brings new insights into the pathogenesis and potential targeted treatment of ischemic AKI.
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