How do lncRNAs regulate transcription
TLDR
Recent progress in elucidating the molecular mechanisms by which lncRNAs modulate gene expression is reviewed, including the act of lnc RNA transcription rather than the lncRNA product that appears to be regulatory.Abstract:
It has recently become apparent that RNA, itself the product of transcription, is a major regulator of the transcriptional process. In particular, long noncoding RNAs (lncRNAs), which are so numerous in eukaryotes, function in many cases as transcriptional regulators. These RNAs function through binding to histone-modifying complexes, to DNA binding proteins (including transcription factors), and even to RNA polymerase II. In other cases, it is the act of lncRNA transcription rather than the lncRNA product that appears to be regulatory. We review recent progress in elucidating the molecular mechanisms by which lncRNAs modulate gene expression and future opportunities in this research field.read more
Citations
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Journal ArticleDOI
RNA delivery by extracellular vesicles in mammalian cells and its applications.
Killian P. O’Brien,Koen Breyne,Stefano Ughetto,Stefano Ughetto,Louise C. Laurent,Xandra O. Breakefield +5 more
TL;DR: This Review focuses on the current state of knowledge pertaining to packaging, transport and function of RNAs in extracellular vesicles and outlines the progress made thus far towards their clinical applications.
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Long Non-Coding RNAs in the Regulation of Gene Expression: Physiology and Disease
Juliane Cristina Ribeiro Fernandes,Stephanie Maia Acuña,Juliana Ide Aoki,Lucile Maria Floeter-Winter,Sandra Marcia Muxel +4 more
TL;DR: Key aspects of lncRNA biology are reviewed, focusing on their role as regulatory elements in gene expression modulation during physiological and disease processes, with implications in host and pathogens physiology, and their role in immune response modulation.
Journal ArticleDOI
Non-Coding RNAs and their Integrated Networks.
TL;DR: This review discusses the distinct types of ncRNAs, including housekeeping n cRNAs and regulatory nc RNAs, their versatile functions and interactions, transcription, translation, and modification, and summarizes the integrated networks of n cRNA interactions, providing a comprehensive landscape of nCRNAs regulatory roles.
Journal ArticleDOI
Long non-coding RNA: Classification, biogenesis and functions in blood cells.
Swati Dahariya,Indira Paddibhatla,Santosh Kumar,Sanjeev Raghuwanshi,Adithya Pallepati,Ravi Kumar Gutti +5 more
TL;DR: The current status of knowledge on lncRNAs classification, biogenesis and its role in blood cells is summarized.
Journal ArticleDOI
Emerging roles of lncRNAs in the post-transcriptional regulation in cancer.
TL;DR: In this paper, the authors discuss latest developments in lncRNA-meditated gene expression at the post-transcriptional level, including gene splicing, mRNA stability, protein stability and nuclear trafficking.
References
More filters
Journal ArticleDOI
Widespread RNA binding by chromatin-associated proteins
David G. Hendrickson,David G. Hendrickson,David R. Kelley,David R. Kelley,Danielle Tenen,Danielle Tenen,Bradley E. Bernstein,John L. Rinn,John L. Rinn,John L. Rinn +9 more
TL;DR: For each protein, the enriched sets of RNAs share distinct biochemical, functional, and chromatin properties, which provide evidence for widespread specific and relevant RNA association across diverse classes of chromatin-modifying complexes.
Journal ArticleDOI
Lysine-Specific Demethylase 1 Regulates the Embryonic Transcriptome and CoREST Stability
Charles T. Foster,Oliver M. Dovey,Larissa Lezina,Jin Li Luo,Timothy W. Gant,Nick Barlev,Allan Bradley,Shaun M. Cowley +7 more
TL;DR: Lysine-specific demethylase 1 regulates the expression and appropriate timing of key developmental regulators, as part of the LSD1/CoREST/HDAC complex, during early embryonic development.
Journal ArticleDOI
ATRX Directs Binding of PRC2 to Xist RNA and Polycomb Targets
Kavitha Sarma,Kavitha Sarma,Catherine Cifuentes-Rojas,Catherine Cifuentes-Rojas,Ayla Ergun,Amanda M. Del Rosario,Yesu Jeon,Yesu Jeon,Forest M. White,Ruslan I. Sadreyev,Jeannie T. Lee +10 more
TL;DR: Epicomic profiling reveals that genome-wide targeting of PRC2 depends on ATRX, as loss of ATR X leads to spatial redistribution ofPRC2 and derepression of Polycomb responsive genes, and ATRx is a required specificity determinant for PRC 2 targeting and function.
Journal ArticleDOI
CTCF regulates the human p53 gene through direct interaction with its natural antisense transcript, Wrap53
Ricardo Saldaña-Meyer,Edgar González-Buendía,Georgina Guerrero,Varun Narendra,Roberto Bonasio,Félix Recillas-Targa,Danny Reinberg +6 more
TL;DR: Par-CLIP-seq analyses indicate that CTCF binds a multitude of transcripts genome-wide as well as to Wrap53 RNA, which may bear directly on its role in establishing higher-order chromatin structures in vivo.
Journal ArticleDOI
The chromosomal high-affinity binding sites for the Drosophila dosage compensation complex.
TL;DR: Combining RNA interference against DCC subunits, limited crosslinking, and chromatin immunoprecipitation coupled to probing high-resolution DNA microarrays, this work identified a set of 131 high-affinity sites for MSL1 and MSL2 and confirmed their properties by various means.
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