How do lncRNAs regulate transcription
TLDR
Recent progress in elucidating the molecular mechanisms by which lncRNAs modulate gene expression is reviewed, including the act of lnc RNA transcription rather than the lncRNA product that appears to be regulatory.Abstract:
It has recently become apparent that RNA, itself the product of transcription, is a major regulator of the transcriptional process. In particular, long noncoding RNAs (lncRNAs), which are so numerous in eukaryotes, function in many cases as transcriptional regulators. These RNAs function through binding to histone-modifying complexes, to DNA binding proteins (including transcription factors), and even to RNA polymerase II. In other cases, it is the act of lncRNA transcription rather than the lncRNA product that appears to be regulatory. We review recent progress in elucidating the molecular mechanisms by which lncRNAs modulate gene expression and future opportunities in this research field.read more
Citations
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Modulation of non-coding RNAs by natural compounds as a potential therapeutical approach in oral cancer: A comprehensive review.
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The role of long noncoding RNAs in regulating invasion and metastasis of malignant tumors.
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Polypharmacology in Drug Design and Discovery—Basis for Rational Design of Multitarget Drugs
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Identification of MALAT1 as a PRC2-Ezh1 Associated lncRNA Essential for Epigenetic Control of Skeletal Muscle Adaptation and Plasticity
TL;DR: It is concluded that Malat1 is an essential partner for PRC2-Ezh1 adaptive function in skeletal muscle cells, allowing epigenetic plastic response to atrophic stress and recovery.
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