How do lncRNAs regulate transcription
TLDR
Recent progress in elucidating the molecular mechanisms by which lncRNAs modulate gene expression is reviewed, including the act of lnc RNA transcription rather than the lncRNA product that appears to be regulatory.Abstract:
It has recently become apparent that RNA, itself the product of transcription, is a major regulator of the transcriptional process. In particular, long noncoding RNAs (lncRNAs), which are so numerous in eukaryotes, function in many cases as transcriptional regulators. These RNAs function through binding to histone-modifying complexes, to DNA binding proteins (including transcription factors), and even to RNA polymerase II. In other cases, it is the act of lncRNA transcription rather than the lncRNA product that appears to be regulatory. We review recent progress in elucidating the molecular mechanisms by which lncRNAs modulate gene expression and future opportunities in this research field.read more
Citations
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Transcriptomics Analysis Reveals a Putative Role for Hormone Signaling and MADS-Box Genes in Mature Chestnut Shoots Rooting Recalcitrance
TL;DR: In this paper , a transcriptomic analysis was developed to compare the gene expression patterns in both types of shoots 24 h after hormone and wounding treatment, matching the induction phase of the process.
Journal ArticleDOI
Effects of autophagy modulators tamoxifen and chloroquine on the expression profiles of long non-coding RNAs in MIAMI cells exposed to IFNγ
Rajkaran Banga,Veerkaran Banga,Amr Eltalla,Lauren Shahin,Sonam Parag,Maha Naim,Easha Iyer,N. Kumrah,Brian Zacharias,Lubov Nathanson,Vladimir Beljanski +10 more
TL;DR: Looking at the putative roles of various differentially regulated lncRNAs in MIAMI cells exposed to IFNγ with (or without) TX or CQ found potential involvement of multiple pro-and anti-inflammatory pathways and molecules in modulating MIAMI Cells’ response to inflammation.
Journal ArticleDOI
Long noncoding RNA H19 synergizes with STAT1 to regulate SNX10 in rheumatoid arthritis.
TL;DR: In this article , H19 upregulation may result in the development of FLS-mediated rheumatoid arthritis via the STAT1/SNX10 axis, and H19 loss significantly alleviated joint redness and swelling and reduced inflammatory response.
Posted ContentDOI
LINC00908 promotes malignant progression and glycolysis in lung adenocarcinoma via interactions with DDX54 and RFX2
TL;DR: In this paper , the authors identified a specific LncRNA, LINC00908, was downregulated in lung adenocarcinoma (LUAD) tissues and associated with good outcome.
Journal ArticleDOI
Comparative study on abortion characteristics of Nsa CMS and Pol CMS and analysis of long non-coding RNAs related to pollen abortion in Brassica napus
TL;DR: The involvement of long non-coding RNAs in anther and pollen development in B.napus has been recognized, but there is little data on the involvement of lncRNAs in pollen abortion in different types of rapeseed CMS as discussed by the authors .
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