How do lncRNAs regulate transcription
TLDR
Recent progress in elucidating the molecular mechanisms by which lncRNAs modulate gene expression is reviewed, including the act of lnc RNA transcription rather than the lncRNA product that appears to be regulatory.Abstract:
It has recently become apparent that RNA, itself the product of transcription, is a major regulator of the transcriptional process. In particular, long noncoding RNAs (lncRNAs), which are so numerous in eukaryotes, function in many cases as transcriptional regulators. These RNAs function through binding to histone-modifying complexes, to DNA binding proteins (including transcription factors), and even to RNA polymerase II. In other cases, it is the act of lncRNA transcription rather than the lncRNA product that appears to be regulatory. We review recent progress in elucidating the molecular mechanisms by which lncRNAs modulate gene expression and future opportunities in this research field.read more
Citations
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Microbial regulation of a lincRNA-miRNA-mRNA network in the mouse hippocampus.
Lanxiang Liu,Haiyang Wang,Ying Yu,Benhua Zeng,Xuechen Rao,Jianjun Chen,Chanjuan Zhou,Peng Zheng,Juncai Pu,Lining Yang,Hanping Zhang,Hong Wei,Peng Xie +12 more
TL;DR: This study provides clues for understanding the molecular basis of gut microbiota-brain interactions in depressive- and anxiety-like behaviors and lincRNA0926-miR-190a-5p-Celf4 interactions may play a pivotal role in this regulatory network.
Journal ArticleDOI
A Review on the Expression Pattern of Non-coding RNAs in Patients With Schizophrenia: With a Special Focus on Peripheral Blood as a Source of Expression Analysis.
Soudeh Ghafouri-Fard,Reyhane Eghtedarian,Mohammad Taheri,Annette Beatrix Brühl,Dena Sadeghi-Bahmani,Dena Sadeghi-Bahmani,Dena Sadeghi-Bahmani,Serge Brand +7 more
TL;DR: In this article, the changes in the expression of miRNAs and lncRNAs in patients with schizophrenia were explored and shown to be dysregulated in blood or brain samples of patients.
Journal ArticleDOI
The Vital Roles of LINC00662 in Human Cancers
TL;DR: The long intergenic non-protein coding RNA 662 (LINC00662) is a novel lncRNA, and accumulating evidence suggests that it is related to a variety of tumors in multiple systems, including the respiratory, reproductive, nervous, and digestive systems as discussed by the authors.
Journal ArticleDOI
The transcriptomic changes associated with the development of social parasitism in the honeybee Apis mellifera capensis.
TL;DR: There was a set of specific transcriptomic changes in the parasitic pseudoqueens that differed from both, queens and social workers, which may be typical for the development of the social parasitism in A. m.
Journal ArticleDOI
Osteoporosis Is Characterized by Altered Expression of Exosomal Long Non-coding RNAs
TL;DR: Results suggest that lncRNAs of serum exosomes could play a significant role in development of osteoporosis and such information may be helpful in developing diagnostic markers and therapeutic modules for osteopOrosis.
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