How do lncRNAs regulate transcription
TLDR
Recent progress in elucidating the molecular mechanisms by which lncRNAs modulate gene expression is reviewed, including the act of lnc RNA transcription rather than the lncRNA product that appears to be regulatory.Abstract:
It has recently become apparent that RNA, itself the product of transcription, is a major regulator of the transcriptional process. In particular, long noncoding RNAs (lncRNAs), which are so numerous in eukaryotes, function in many cases as transcriptional regulators. These RNAs function through binding to histone-modifying complexes, to DNA binding proteins (including transcription factors), and even to RNA polymerase II. In other cases, it is the act of lncRNA transcription rather than the lncRNA product that appears to be regulatory. We review recent progress in elucidating the molecular mechanisms by which lncRNAs modulate gene expression and future opportunities in this research field.read more
Citations
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Journal ArticleDOI
RNA delivery by extracellular vesicles in mammalian cells and its applications.
Killian P. O’Brien,Koen Breyne,Stefano Ughetto,Stefano Ughetto,Louise C. Laurent,Xandra O. Breakefield +5 more
TL;DR: This Review focuses on the current state of knowledge pertaining to packaging, transport and function of RNAs in extracellular vesicles and outlines the progress made thus far towards their clinical applications.
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Long Non-Coding RNAs in the Regulation of Gene Expression: Physiology and Disease
Juliane Cristina Ribeiro Fernandes,Stephanie Maia Acuña,Juliana Ide Aoki,Lucile Maria Floeter-Winter,Sandra Marcia Muxel +4 more
TL;DR: Key aspects of lncRNA biology are reviewed, focusing on their role as regulatory elements in gene expression modulation during physiological and disease processes, with implications in host and pathogens physiology, and their role in immune response modulation.
Journal ArticleDOI
Non-Coding RNAs and their Integrated Networks.
TL;DR: This review discusses the distinct types of ncRNAs, including housekeeping n cRNAs and regulatory nc RNAs, their versatile functions and interactions, transcription, translation, and modification, and summarizes the integrated networks of n cRNA interactions, providing a comprehensive landscape of nCRNAs regulatory roles.
Journal ArticleDOI
Long non-coding RNA: Classification, biogenesis and functions in blood cells.
Swati Dahariya,Indira Paddibhatla,Santosh Kumar,Sanjeev Raghuwanshi,Adithya Pallepati,Ravi Kumar Gutti +5 more
TL;DR: The current status of knowledge on lncRNAs classification, biogenesis and its role in blood cells is summarized.
Journal ArticleDOI
Emerging roles of lncRNAs in the post-transcriptional regulation in cancer.
TL;DR: In this paper, the authors discuss latest developments in lncRNA-meditated gene expression at the post-transcriptional level, including gene splicing, mRNA stability, protein stability and nuclear trafficking.
References
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PRC2 is dispensable for HOTAIR‐mediated transcriptional repression
Manuela Portoso,Manuela Portoso,Roberta Ragazzini,Roberta Ragazzini,Živa Brenčič,Živa Brenčič,Arianna Moiani,Arianna Moiani,Audrey Michaud,Audrey Michaud,Ivaylo Vassilev,Ivaylo Vassilev,Michel Wassef,Michel Wassef,Nicolas Servant,Nicolas Servant,Bruno Sargueil,Raphaël Margueron,Raphaël Margueron +18 more
TL;DR: Surprisingly, it is observed that forced overexpression of HOTAIR in breast cancer cells leads to subtle transcriptomic changes that appear to be independent of PRC2, and it is proposed thatPRC2 binding to RNA might serve functions other than chromatin targeting.
Journal ArticleDOI
Linc-YY1 promotes myogenic differentiation and muscle regeneration through an interaction with the transcription factor YY1
Liang Zhou,Kun Sun,Yu Zhao,Suyang Zhang,X.M. Wang,Yuying Li,Leina Lu,Xiaona Chen,Fengyuan Chen,Xichen Bao,Xihua Zhu,Lijun Wang,Ling Yin Tang,Miguel A. Esteban,Chi Chiu Wang,Ralf Jauch,Hao Sun,Huating Wang +17 more
TL;DR: It is demonstrated that Linc-YY1 is dynamically regulated during myogenesis in vitro and in vivo, and a previously unappreciated mechanism of gene regulation by lincRNA is uncovered.
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PRC1 complex diversity: where is it taking us?
Jesús Gil,Ana O'Loghlen +1 more
TL;DR: The mechanisms by which canonical and non-canonical PRC1 are recruited to chromatin are discussed, their role in normal development and disease, and emerging evidence forPRC1 as a transcriptional activator are discussed.
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Quiescence-Induced LncRNAs Trigger H4K20 Trimethylation and Transcriptional Silencing
Holger Bierhoff,Marcel Andre Dammert,David Brocks,Silvia Dambacher,Gunnar Schotta,Ingrid Grummt +5 more
TL;DR: The results uncover a lncRNA-mediated mechanism that guides Suv4-20h2 to specific genomic loci to establish a more compact chromatin structure in growth-arrested cells.
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linc-HOXA1 is a noncoding RNA that represses Hoxa1 transcription in cis
TL;DR: In this paper, the authors used transcript counting and spatial localization to characterize a lncRNA (dubbed linc-HOXA1) located ∼50 kb from the Hoxa gene cluster in mouse embryonic stem cells.
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