How do lncRNAs regulate transcription
TLDR
Recent progress in elucidating the molecular mechanisms by which lncRNAs modulate gene expression is reviewed, including the act of lnc RNA transcription rather than the lncRNA product that appears to be regulatory.Abstract:
It has recently become apparent that RNA, itself the product of transcription, is a major regulator of the transcriptional process. In particular, long noncoding RNAs (lncRNAs), which are so numerous in eukaryotes, function in many cases as transcriptional regulators. These RNAs function through binding to histone-modifying complexes, to DNA binding proteins (including transcription factors), and even to RNA polymerase II. In other cases, it is the act of lncRNA transcription rather than the lncRNA product that appears to be regulatory. We review recent progress in elucidating the molecular mechanisms by which lncRNAs modulate gene expression and future opportunities in this research field.read more
Citations
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Book ChapterDOI
RNA 3D Structure Comparison Using RNA-Puzzles Toolkit.
Marcin Magnus,Zhichao Miao +1 more
Journal ArticleDOI
SALIS transcriptionally represses IGFBP3/Caspase-7-mediated apoptosis by associating with STAT5A to promote hepatocellular carcinoma
Xing-qing Liu,Yi Jin,Xuan Wan,Xiaoting Liang,Ke Wang,Jieyu Liu,Jiale Jiang,Bingyao Meng,Shuo Han,Liang Zhou,Shaoxi Cai,Fei Zou +11 more
TL;DR: Wang et al. as mentioned in this paper identified a LncRNA, termed SALIS (Suppression of Apoptosis by LINC01186 Interacting with STAT5A), which functions in promoting the proliferation, colony formation, migration and invasion while suppressing apoptosis in HCC cells.
Journal ArticleDOI
Lnc Tmem235 promotes repair of early steroid-induced osteonecrosis of the femoral head by inhibiting hypoxia-induced apoptosis of BMSCs
Fei Zhang,Wuxun Peng,Tao Wang,Jianli Zhang,Wentao Dong,Chuan-song Wang,Zhihong Xie,Hong Luo,Gang Liu +8 more
TL;DR: In this article , the authors showed that the long noncoding RNA (Lnc) transmembrane protein 235 (Tmem235) exhibited competitive binding to miR-34a-3p compared with BIRC5 mRNA, which is an inhibitor of apoptosis.
Posted ContentDOI
Unexpected features of GC-AG introns in long non-coding and protein-coding genes suggest a new role as regulatory elements
TL;DR: This study exploited recent annotations provided by the GENCODE project to characterize the genomic and splicing features of lnc-genes in comparison to protein-coding ones, both in human and mouse, and suggested that GC-AG introns could represent new regulatory elements mainly associated with l NCs.
Journal ArticleDOI
Oxidative stress‐induced <scp>lncRNA CYLD‐AS1</scp> promotes <scp>RPE</scp> inflammation via Nrf2/ <scp>miR</scp> ‐134‐5p/ <scp>NF‐κB</scp> signaling pathway
TL;DR: Zhang et al. as mentioned in this paper identified a novel oxidation-related lncRNA named CYLD-AS1, which increased the expression of RPEs during oxidative stress and protected RPE cells against hydrogen peroxide (H2 O2 )-induced damage.
References
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