How do lncRNAs regulate transcription
TLDR
Recent progress in elucidating the molecular mechanisms by which lncRNAs modulate gene expression is reviewed, including the act of lnc RNA transcription rather than the lncRNA product that appears to be regulatory.Abstract:
It has recently become apparent that RNA, itself the product of transcription, is a major regulator of the transcriptional process. In particular, long noncoding RNAs (lncRNAs), which are so numerous in eukaryotes, function in many cases as transcriptional regulators. These RNAs function through binding to histone-modifying complexes, to DNA binding proteins (including transcription factors), and even to RNA polymerase II. In other cases, it is the act of lncRNA transcription rather than the lncRNA product that appears to be regulatory. We review recent progress in elucidating the molecular mechanisms by which lncRNAs modulate gene expression and future opportunities in this research field.read more
Citations
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Journal ArticleDOI
Regulation of bone marrow mesenchymal stem cell fate by long non-coding RNA.
TL;DR: The role of lncRNA in several critical signaling pathways which involved in regulates osteo-adipogenesis of BMSC and prospects the potential clinical application of lNCRNA are focused on.
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Recent Advances in Machine Learning Based Prediction of RNA-protein Interactions
Amit Sagar,Bin Xue +1 more
TL;DR: In this review, the recent advances on RNA-protein interaction were summarized in three aspects, including prediction strategies, input features, and datasets.
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Investigation of long non-coding RNAs as regulatory players of grapevine response to powdery and downy mildew infection
TL;DR: In this paper, the role of long non-coding RNAs (lncRNAs) is investigated in Vitis vinifera (grapevine) in response to obligate biotrophic fungal phytopathogens, Erysiphe necator (powdery mildew, PM) and Plasmopara viticola (downy mildw, DM), which impose huge agroeconomic burden on grape-growers worldwide.
Journal ArticleDOI
In silico analysis of long non-coding RNAs in medulloblastoma and its subgroups.
TL;DR: The results identify putative candidate lncRNAs that could be evaluated for their functional role in medulloblastoma genesis and progression or as diagnostic and prognostic biomarkers, and identify a 17-lncRNA prognostic model using LASSO based penalized Cox' PH model.
Journal ArticleDOI
Diverse roles of long non-coding RNAs in viral diseases
Lucy Ginn,Lucy Ginn,Manuela La Montagna,Manuela La Montagna,Qinghua Wu,Qinghua Wu,Lei Shi,Lei Shi +7 more
TL;DR: The current knowledge of lncRNAs and their functions in viral infections with a specific focus on host‐virus responses is summarized and the potential implications of lNCRNAs in severe acute respiratory syndrome coronavirus 2 will be discussed.
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