How do lncRNAs regulate transcription
TLDR
Recent progress in elucidating the molecular mechanisms by which lncRNAs modulate gene expression is reviewed, including the act of lnc RNA transcription rather than the lncRNA product that appears to be regulatory.Abstract:
It has recently become apparent that RNA, itself the product of transcription, is a major regulator of the transcriptional process. In particular, long noncoding RNAs (lncRNAs), which are so numerous in eukaryotes, function in many cases as transcriptional regulators. These RNAs function through binding to histone-modifying complexes, to DNA binding proteins (including transcription factors), and even to RNA polymerase II. In other cases, it is the act of lncRNA transcription rather than the lncRNA product that appears to be regulatory. We review recent progress in elucidating the molecular mechanisms by which lncRNAs modulate gene expression and future opportunities in this research field.read more
Citations
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Journal ArticleDOI
Interrogating lncRNA functions via CRISPR/Cas systems.
TL;DR: Long noncoding RNAs (lncRNAs) are an increasing focus of investigation due to their implications in diverse biological processes and disease as discussed by the authors. Nevertheless, the majority of lnc RNAs are low in abunda...
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Role of epigenetic mechanisms regulated by enhancers and long noncoding RNAs in cardiovascular disease.
TL;DR: Epigenomic approaches in cells affected in CVDs can be exploited to understand the function of genetic polymorphisms at cis-regulatory elements and crosstalk between enhancers and lncRNAs associated with disease susceptibility and progression.
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Long Non-coding RNA LINC00847 Induced by E2F1 Accelerates Non-small Cell Lung Cancer Progression Through Targeting miR-147a/IFITM1 Axis.
TL;DR: In this paper, the expression and function of LncRNA LINC00847 in non-small cell lung cancer (NSCLC) have not been investigated and the clinical significance of Linc00847 was statistically analyzed.
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The long non-coding RNA lnc-HLX-2-7 is oncogenic in group 3 medulloblastomas
Keisuke Katsushima,Bongyong Lee,Haritha Kunhiraman,Cuncong Zhong,Rabi Murath,Jun Ying,Ben Liu,Alexandra Garancher,Ignacio Gonzalez-Gomez,Stacie Stapleton,Rajeev Vibhakar,Chetan Bettegowda,Robert J. Wechsler-Reya,George I. Jallo,Eric H. Raabe,Charles G. Eberhart,Ranjan J Perera +16 more
TL;DR: In vitro and in vivo studies strongly support an oncogenic role for lnc-HLX2-7 in group 3 medulloblastoma and represent a promising novel molecular marker and a potential therapeutic target in group 2 MBs in children.
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Long Noncoding RNAs and Their Therapeutic Promise in Diabetic Nephropathy.
TL;DR: In this paper, the authors provide an overview of the main functions and mechanisms of actions of lncRNAs, and their promise as therapeutic targets in kidney diseases, emphasizing on the role of some of the best-characterized long noncoding RNAs implicated in the pathogenesis and progression of diabetic nephropathy.
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