How do lncRNAs regulate transcription
TLDR
Recent progress in elucidating the molecular mechanisms by which lncRNAs modulate gene expression is reviewed, including the act of lnc RNA transcription rather than the lncRNA product that appears to be regulatory.Abstract:
It has recently become apparent that RNA, itself the product of transcription, is a major regulator of the transcriptional process. In particular, long noncoding RNAs (lncRNAs), which are so numerous in eukaryotes, function in many cases as transcriptional regulators. These RNAs function through binding to histone-modifying complexes, to DNA binding proteins (including transcription factors), and even to RNA polymerase II. In other cases, it is the act of lncRNA transcription rather than the lncRNA product that appears to be regulatory. We review recent progress in elucidating the molecular mechanisms by which lncRNAs modulate gene expression and future opportunities in this research field.read more
Citations
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The Mechanism Underlying the ncRNA Dysregulation Pattern in Hepatocellular Carcinoma and Its Tumor Microenvironment
TL;DR: The role of ncRNAs in the TME in the regulation of tumor cell proliferation, invasion, migration, immune cell infiltration and functional activation may provide a foundation for the development of promising potential prognostic/predictive biomarkers and novel therapies for HCC patients.
Journal ArticleDOI
Downregulation of LNMAS orchestrates partial EMT and immune escape from macrophage phagocytosis to promote lymph node metastasis of cervical cancer
Yuandong Liao,Pan Liu,Chunyu Zhang,Junxiu Liu,Meng Xia,Chunliang Shang,Shiyin Ooi,Yili Chen,Shuhang Qin,Qiqiao Du,Tianyu Liu,Manman Xu,Qiaojian Zou,Yijia Zhou,Huankun Huang,Yuwen Pan,Wei Wang,Shuzhong Yao +17 more
TL;DR: Wang et al. as discussed by the authors identified a lncRNA termed lymph node metastasis associated suppressor (LNMAS), which was downregulated in LN-positive cervical cancer patients and correlated with LN metastasis and prognosis.
Journal ArticleDOI
The social construction of the social epigenome and the larger biological context.
TL;DR: While research labelled epigenetics contributes significantly to the authors' knowledge about chromatin and the genome, it does not, as is often claimed, rehabilitate Lamarck or overthrow the fundamental biological principles of gene regulation, which are based on specific regulatory sequences of the genome.
Journal ArticleDOI
Role of long non-coding RNAs on the regulation of Nrf2 in chronic diseases.
TL;DR: In this paper, a review on the regulation of Nrf2 in different responses and the potential role of specific lncRNA in modulating its transcriptional activities is presented. But, the review only focuses on the NRF2 signaling pathway in response to various stimuli, including stress.
Journal ArticleDOI
Functional impact of the long non-coding RNA MEG3 deletion by CRISPR/Cas9 in the human triple negative metastatic Hs578T cancer cell line.
Carlos Deocesano‑Pereira,Raquel A. C. Machado,Henrique Cesar de Jesus‑Ferreira,Thiago Marchini,Tulio Felipe Pereira,Ana Claudia Oliveira Carreira,Mari Cleide Sogayar +6 more
TL;DR: The present study demonstrated that deletion of MEG3 promoted an increase in transforming growth factor β and N-cadherin protein levels and significant reduction in matrix metallopeptidase 2, zinc-finger E-box binding homeobox 1 and collagen type III α1 chain gene expression levels, demonstrating the role of this lncRNA in cancer cell survival by regulating apoptosis.
References
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