How do lncRNAs regulate transcription
TLDR
Recent progress in elucidating the molecular mechanisms by which lncRNAs modulate gene expression is reviewed, including the act of lnc RNA transcription rather than the lncRNA product that appears to be regulatory.Abstract:
It has recently become apparent that RNA, itself the product of transcription, is a major regulator of the transcriptional process. In particular, long noncoding RNAs (lncRNAs), which are so numerous in eukaryotes, function in many cases as transcriptional regulators. These RNAs function through binding to histone-modifying complexes, to DNA binding proteins (including transcription factors), and even to RNA polymerase II. In other cases, it is the act of lncRNA transcription rather than the lncRNA product that appears to be regulatory. We review recent progress in elucidating the molecular mechanisms by which lncRNAs modulate gene expression and future opportunities in this research field.read more
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A novel long noncoding RNA FAF inhibits apoptosis via upregulating FGF9 through PI3K/AKT signaling pathway in ischemia-hypoxia cardiomyocytes.
Hao-Jie Shi,Ming-Wei Wang,Jia-Teng Sun,Hao Wang,Ya-Fei Li,Bing-Rui Chen,Yi Fan,Si-Bo Wang,Zi-Mu Wang,Qi-Ming Wang,Lian-Sheng Wang +10 more
TL;DR: Mechanistically, FGF9 inhibited cardiomyocytes apoptosis through activating signaling tyrosine kinase FGFR2 via phosphoinositide 3‐kinase/protein kinase B signaling pathway and may serve as a treatment target for AMI.
Journal ArticleDOI
Silencing of lncRNA LINC00857 Enhances BIRC5-Dependent Radio-Sensitivity of Lung Adenocarcinoma Cells by Recruiting NF-κB1.
TL;DR: The results reveal a functional regulatory LINC00857-NF-κB1-BIRC5 triplet in LUAD cells, suggesting Linc00857 as a potential target for LUAD treatment.
Journal ArticleDOI
Integrative analyses of noncoding RNAs reveal the potential mechanisms augmenting tumor malignancy in lung adenocarcinoma
Jou Ho Shih,Jou Ho Shih,Hsin Yi Chen,Shin Chih Lin,Shin Chih Lin,Yi Chen Yeh,Roger Shen,Roger Shen,Yaw Dong Lang,Dung Chi Wu,Chien-Yu Chen,Ruey-Hwa Chen,Teh Ying Chou,Yuh-Shan Jou,Yuh-Shan Jou,Yuh-Shan Jou +15 more
TL;DR: Overall, a systematic strategy to uncover prognostic ncRNAs with functional prediction methods suitable for pan-cancer studies is established and it is revealed that PTTG3P, due to its upregulation of the PTTg3P/FOXM1/BUB1B axis, could be a therapeutic target for LUAD patients.
Journal ArticleDOI
The long noncoding RNA TP73-AS1 promotes tumorigenicity of medulloblastoma cells
Mor Varon,Tal Levy,Gal Mazor,Hila Ben David,Ran Marciano,Yakov Krelin,Manu Prasad,Moshe Elkabets,David Pauck,Ulvi Ahmadov,Daniel Picard,Nan Qin,Arndt Borkhardt,Guido Reifenberger,Gabriel Leprivier,Marc Remke,Barak Rotblat +16 more
TL;DR: This study suggests that the lncRNA TP73‐AS1 is a prognostic marker and therapeutic target in medulloblastoma tumors and serves as a proof of concept that lncRNAs are important factors in the disease.
Journal ArticleDOI
The Impact of Long Non-Coding RNAs in the Pathogenesis of Hepatocellular Carcinoma.
TL;DR: In this paper, the impact of long non-coding RNAs (lncRNAs) on the pathogenesis of hepatocellular carcinoma (HCC) was discussed.
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