How do lncRNAs regulate transcription
TLDR
Recent progress in elucidating the molecular mechanisms by which lncRNAs modulate gene expression is reviewed, including the act of lnc RNA transcription rather than the lncRNA product that appears to be regulatory.Abstract:
It has recently become apparent that RNA, itself the product of transcription, is a major regulator of the transcriptional process. In particular, long noncoding RNAs (lncRNAs), which are so numerous in eukaryotes, function in many cases as transcriptional regulators. These RNAs function through binding to histone-modifying complexes, to DNA binding proteins (including transcription factors), and even to RNA polymerase II. In other cases, it is the act of lncRNA transcription rather than the lncRNA product that appears to be regulatory. We review recent progress in elucidating the molecular mechanisms by which lncRNAs modulate gene expression and future opportunities in this research field.read more
Citations
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Identification of key lncRNAs in the tumorigenesis of intraductal pancreatic mucinous neoplasm by coexpression network analysis.
TL;DR: By coexpression network analysis of the lncRNA profiles, three key lncRNAs were identified in association with the tumorigenesis of IPMN, and those lnc RNAs might act as early diagnostic biomarkers or therapeutic targets in pancreatic cancer.
Journal ArticleDOI
Assessing the Role of Long Noncoding RNA in Nucleus Accumbens in Subjects With Alcohol Dependence
John Drake,Gowon O. McMichael,Eric Vornholt,Kellen Garrison Cresswell,Vernell Williamson,Chris Chatzinakos,Mohammed Mamdani,Siddharth Hariharan,Kenneth S. Kendler,Gursharan Kalsi,Brien P. Riley,Mikhail G. Dozmorov,Michael F. Miles,Silviu Alin Bacanu,Vladimir I. Vladimirov +14 more
TL;DR: This study identified lncRNA and gene networks significantly associated with AD in the NAc, coordinated l NCRNA and mRNA coexpression changes, highlighting potentially regulatory functions for the lnc RNA, and the genetic analysis provides novel insights into the etiological mechanisms of AD.
Journal ArticleDOI
Profiles of Long Non-Coding RNAs and mRNA Expression in Human Macrophages Regulated by Interleukin-27.
Xiaojun Hu,Suranjana Goswami,Ju Qiu,Qian Chen,Sylvain Laverdure,Brad T. Sherman,Tomozumi Imamichi +6 more
TL;DR: This study investigated the expression profiles of mRNA and lncRNA in human monocyte-derived macrophages regulated by IL-27 and identified 146 lncRNAs (including 88 novel ones) and 434 coding genes were differentially regulated byIL-27 in both M-CSF- and AB serum-induced Macrophages.
Journal ArticleDOI
GC-AG Introns Features in Long Non-coding and Protein-Coding Genes Suggest Their Role in Gene Expression Regulation.
TL;DR: This study shows for the first time that GC-AG introns are mainly associated with lncRNAs and are preferentially located in the first intron, and discovers their regulatory potential indicating the existence of a new mechanism of non-coding and PCGs expression regulation.
Journal ArticleDOI
A Risk Signature with Autophagy-Related Long Noncoding RNAs for Predicting the Prognosis of Clear Cell Renal Cell Carcinoma: Based on the TCGA Database and Bioinformatics
TL;DR: In this paper, the authors identified and validated the candidate prognostic long noncoding RNA signature of autophagy, which was a linear combination of the regression coefficients from the multivariate Cox regression model ( ) multiplied by the expression levels of the respective ARlncRNAs in the training cohort.
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