Journal ArticleDOI
Noninvasive Imaging of Quantum Dots in Mice
TLDR
Long-term experiments demonstrated that these quantum dots remain fluorescent after at least four months in vivo, using only quantum dots for detection.About:
This article is published in Bioconjugate Chemistry.The article was published on 2004-01-01. It has received 1153 citations till now. The article focuses on the topics: Quantum dot & Fluorescence-lifetime imaging microscopy.read more
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Study on the stability of suspensions based on biomimetic apatites aimed at biomedical applications
TL;DR: It is shown that various physico-chemical characteristics of the suspension vary with time, including viscosity and mean particle size, suggesting a progressive structuration of the suspensions, and the addition of glucose prior to freeze-drying was found to be an effective way to avoid the formation of aggregates during drying.
Journal ArticleDOI
Effects of Cd-based Quantum Dot Exposure on the Reproduction and Offspring of Kunming Mice over Multiple Generations.
Jianwei Liu,Chengbin Yang,Jing Liu,Rui Hu,Yazhuo Hu,Hongyan Chen,Wing Cheung Law,Mark T. Swihart,Ling Ye,Kuan Wang,Ken-Tye Yong +10 more
TL;DR: Investigation of the effects of QDs on reproductive outcomes in Kunming mice across three generations shows that QD exposure with a short buffering period before conception does not cause obvious pregnancy complications or significant toxicity effects in treated mice or their offspring, and indicates that a shortbuffering period after QDs exposure may reduce potential risk of QD to reproductive health.
Journal ArticleDOI
Plasma kinetics and biodistribution of water-soluble CdTe quantum dots in mice: a comparison between Cd and Te
Ying Han,Guangyun Xie,Guangyun Xie,Zhiwei Sun,Ying Mu,Sihai Han,Yang Xiao,Na Liu,Hui Wang,Caixia Guo,Zhixiong Shi,Yanbo Li,Peili Huang +12 more
TL;DR: Water-soluble quantum dots have shown potential as tumor diagnostic agents but little is known about their biological behaviors in vivo, and the different plasma kinetics and distribution patterns of Cd and Te imply that CdTe QDs have been part of the degradation or aggregation in vivo.
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Fluorescent II-VI Semiconductor Quantum Dots in Living Cells : Nonlinear Microspectroscopy in an Optical Tweezers System
Patricia M. A. Farias,Beate S. Santos,André A. de Thomaz,Ricardo B. Ferreira,Frederico Duarte de Menezes,Carlos L. Cesar,Adriana Fontes +6 more
TL;DR: The results obtained show the potential presented by this system as well as by these II-VI fluorescent semiconductor quantum dots to perform spectroscopy in living trapped cells in any neighborhood and dynamically observe the cell chemical reactions in real time.
Journal ArticleDOI
Proximity-activated nanoparticles: in vitro performance of specific structural modification by enzymatic cleavage
TL;DR: The development and in vitro performance of a modular nanoscale system capable of specific structural modification by enzymatic activity is described, which has the capability to integrate characteristics for detection, biosensing, targeting, and payload delivery into a single, multifunctional nanoparticle structure.
References
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Journal ArticleDOI
Semiconductor Nanocrystals as Fluorescent Biological Labels
TL;DR: Semiconductor nanocrystals prepared for use as fluorescent probes in biological staining and diagnostics have a narrow, tunable, symmetric emission spectrum and are photochemically stable.
Journal ArticleDOI
Quantum Dot Bioconjugates for Ultrasensitive Nonisotopic Detection
Warren C. W. Chan,Shuming Nie +1 more
TL;DR: Highly luminescent semiconductor quantum dots (zinc sulfide-capped cadmium selenide) have been covalently coupled to biomolecules for use in ultrasensitive biological detection and these nanometer-sized conjugates are water-soluble and biocompatible.
Journal Article
Long-Circulating and Target-Specific Nanoparticles: Theory to Practice
TL;DR: The surface mechanisms, which affords red blood cells long-circulatory lives and the ability of specific microorganisms to evade macrophage recognition, are explored and the rational approaches in the design as well as the biological performance of such constructs are assessed.
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Nanoparticles in cancer therapy and diagnosis
TL;DR: The in vivo fate of these systems, after intravascular or tumoral administration, is discussed, as well as the mechanism involved in tumor regression, and the application of nanoparticles in imaging for cancer diagnosis is focused on.
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Effect of pegylation on pharmaceuticals
J. Milton Harris,Robert B. Chess +1 more
TL;DR: How PEGylation can result in drugs that are often more effective and safer, and which show improved patient convenience and compliance are reviewed.