Journal ArticleDOI
Noninvasive Imaging of Quantum Dots in Mice
TLDR
Long-term experiments demonstrated that these quantum dots remain fluorescent after at least four months in vivo, using only quantum dots for detection.About:
This article is published in Bioconjugate Chemistry.The article was published on 2004-01-01. It has received 1153 citations till now. The article focuses on the topics: Quantum dot & Fluorescence-lifetime imaging microscopy.read more
Citations
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Journal ArticleDOI
Quantum Dots for Live Cells, in Vivo Imaging, and Diagnostics
Xavier Michalet,Fabien Pinaud,Laurent A. Bentolila,James M. Tsay,Sören Doose,J. Jack Li,Gobalakrishnan Sundaresan,Anna M. Wu,Sanjiv S. Gambhir,Sanjiv S. Gambhir,Shimon Weiss +10 more
TL;DR: The new generations of qdots have far-reaching potential for the study of intracellular processes at the single-molecule level, high-resolution cellular imaging, long-term in vivo observation of cell trafficking, tumor targeting, and diagnostics.
Journal ArticleDOI
Nanotoxicology: An Emerging Discipline Evolving from Studies of Ultrafine Particles
TL;DR: Results of older bio-kinetic studies with NSPs and newer epidemiologic and toxicologic studies with airborne ultrafine particles can be viewed as the basis for the expanding field of nanotoxicology, which can be defined as safety evaluation of engineered nanostructures and nanodevices.
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Quantum dot bioconjugates for imaging, labelling and sensing
TL;DR: This review looks at current methods for preparing QD bioconjugates as well as presenting an overview of applications, and concludes that the potential of QDs in biology has just begun to be realized and new avenues will arise as the ability to manipulate these materials improves.
Journal ArticleDOI
In vivo cancer targeting and imaging with semiconductor quantum dots
TL;DR: Sensitive and multicolor fluorescence imaging of cancer cells under in vivo conditions are achieved and a whole-body macro-illumination system with wavelength-resolved spectral imaging is integrated for efficient background removal and precise delineation of weak spectral signatures.
Journal ArticleDOI
Quantum dots versus organic dyes as fluorescent labels
TL;DR: This work compares and evaluates the differences in physicochemical properties of common fluorescent labels, focusing on traditional organic dyes and QDs, to provide a better understanding of the advantages and limitations of both classes of chromophores.
References
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Journal ArticleDOI
Quantum-dot nanocrystals for ultrasensitive biological labeling and multicolor optical encoding.
TL;DR: It is shown that the optical properties of ZnS-capped CdSe quantum dots are sensitive to environmental factors such as pH and divalent cations, leading to the potential use of quantum dots in molecular sensing.
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PEG drugs: an overview
TL;DR: This recent resuscitation of small organic molecule delivery by high molecular weight PEG conjugates was founded on meaningful in vivo testing using established tumor models, and has led to a clinical candidate.
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Targeting cell surface receptors with ligand-conjugated nanocrystals.
Sandra J. Rosenthal,Ian D. Tomlinson,Erika M. Adkins,Sally Schroeter,Scott V. Adams,Laura A. Swafford,James R. McBride,Yongqiang Wang,Louis J. DeFelice,Randy D. Blakely +9 more
TL;DR: Electrophysiology measurements indicated that LSNACs did not elicit currents from the serotonin-3 (5HT(3)) receptor but did produce currents when exposed to the transporter, which are similar to those elicited by antagonists.
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Multiplexed SNP genotyping using the Qbead™ system: a quantum dot‐encoded microsphere‐based assay
Hongxia Xu,Michael Y. Sha,Edith Y. Wong,Janet Uphoff,Yanzhang Xu,Joseph A. Treadway,Anh Truong,Eamonn O’Brien,Steven Asquith,Michael Stubbins,Nigel K. Spurr,Eric Lai,Walt Mahoney +12 more
TL;DR: The Qbead system was validated as an accurate and reliable technique for multiplexed SNP genotyping and has the potential to be a robust and cost-effective platform for a number of applications.
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Biodistribution of long-circulating PEG-grafted nanocapsules in mice: effects of PEG chain length and density.
Vanessa Carla Furtado Mosqueira,Philippe Legrand,Jean-Louis Morgat,Michel Vert,Evgueni Mysiakine,Ruxandra Gref,Jean-Philippe Devissaguet,Gillian Barratt +7 more
TL;DR: A dramatic difference in the pharmacokinetic parameters of PLA-PEG 45-20 30% NCs compared to poloxamer-coated NCs indicates that covalent attachment, longer PEG chain lengths, and higher densities are necessary to produce an increased half-life of NCs in vivo.