Journal ArticleDOI
Noninvasive Imaging of Quantum Dots in Mice
TLDR
Long-term experiments demonstrated that these quantum dots remain fluorescent after at least four months in vivo, using only quantum dots for detection.About:
This article is published in Bioconjugate Chemistry.The article was published on 2004-01-01. It has received 1153 citations till now. The article focuses on the topics: Quantum dot & Fluorescence-lifetime imaging microscopy.read more
Citations
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Journal ArticleDOI
Quantitative imaging and in situ concentration measurements of quantum dot nanomaterials in variably saturated porous media
TL;DR: In this article, a light transmission and fluorescence method was developed to visualize and measure in situ concentrations of quantum dot (QD) nanoparticles in variably saturated environments, and a linear relationship was observed between hue-intensity ratio values and QD concentrations for constant water saturation levels.
Proceedings ArticleDOI
Peptide-coated semiconductor nanocrystals for biomedical applications.
Xavier Michalet,Fabien Pinaud,Laurent A. Bentolila,James M. Tsay,Soeren Doose,Jianqing J. Li,Gopal Iyer,Shimon Weiss +7 more
TL;DR: In this article, a peptide-coating technique was used to yield small, monodisperse and very stable water-soluble core and core-shell nanocrystals that remain bright and photostable.
Journal ArticleDOI
Hepatotoxicity of Cadmium Telluride Quantum Dots Induced by Mitochondrial Dysfunction.
Kathy C Nguyen,Kathy C Nguyen,Yan Zhang,Julie Todd,Kelvin Kittle,Michelle Lalande,Scott Smith,Douglas Parks,Martha Navarro,Azam F. Tayabali,Azam F. Tayabali,William G. Willmore +11 more
TL;DR: The findings from this study suggest that CdTe-QDs induced hepatotoxicity might have originated from mitochondrial effects which resulted in oxidative stress and apoptosis in the liver cells.
Journal ArticleDOI
In vitro and in vivo intracellular delivery of quantum dots by maurocalcine
Narendra Ram,Isabelle Texier-Nogues,Karine Pernet-Gallay,Cathy Poillot,Fabienne Pirollet,Michel Ronjat,Annie Andrieux,Christophe Arnoult,Toufic Daou,Michel De Waard +9 more
TL;DR: It is reported for the first time that this peptide is able to deliver quantum dots inside a variety of cells, both in vitro and in vivo, and can be used for intracellular delivery of functionalised nanoparticles in vivo.
Book ChapterDOI
Quantum Dots in Targeted Delivery of Bioactives and Imaging
TL;DR: This chapter has discussed recent advances in the development of QDs and various biomedical applications including bioimaging as well as the targeted delivery of drugs and genes.
References
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Journal ArticleDOI
Semiconductor Nanocrystals as Fluorescent Biological Labels
TL;DR: Semiconductor nanocrystals prepared for use as fluorescent probes in biological staining and diagnostics have a narrow, tunable, symmetric emission spectrum and are photochemically stable.
Journal ArticleDOI
Quantum Dot Bioconjugates for Ultrasensitive Nonisotopic Detection
Warren C. W. Chan,Shuming Nie +1 more
TL;DR: Highly luminescent semiconductor quantum dots (zinc sulfide-capped cadmium selenide) have been covalently coupled to biomolecules for use in ultrasensitive biological detection and these nanometer-sized conjugates are water-soluble and biocompatible.
Journal Article
Long-Circulating and Target-Specific Nanoparticles: Theory to Practice
TL;DR: The surface mechanisms, which affords red blood cells long-circulatory lives and the ability of specific microorganisms to evade macrophage recognition, are explored and the rational approaches in the design as well as the biological performance of such constructs are assessed.
Journal ArticleDOI
Nanoparticles in cancer therapy and diagnosis
TL;DR: The in vivo fate of these systems, after intravascular or tumoral administration, is discussed, as well as the mechanism involved in tumor regression, and the application of nanoparticles in imaging for cancer diagnosis is focused on.
Journal ArticleDOI
Effect of pegylation on pharmaceuticals
J. Milton Harris,Robert B. Chess +1 more
TL;DR: How PEGylation can result in drugs that are often more effective and safer, and which show improved patient convenience and compliance are reviewed.