Journal ArticleDOI
Noninvasive Imaging of Quantum Dots in Mice
TLDR
Long-term experiments demonstrated that these quantum dots remain fluorescent after at least four months in vivo, using only quantum dots for detection.About:
This article is published in Bioconjugate Chemistry.The article was published on 2004-01-01. It has received 1153 citations till now. The article focuses on the topics: Quantum dot & Fluorescence-lifetime imaging microscopy.read more
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Journal ArticleDOI
Histochemical analyses and quantum dot imaging of microvascular blood flow with pulmonary edema in living mouse lungs by "in vivo cryotechnique".
TL;DR: To demonstrate dynamically changing morphology and immunohistochemical images of their living states, in vivo cryotechnique (IVCT) combined with freeze-substitution fixation was applied to anesthetized mouse lungs.
Journal ArticleDOI
A single molecule investigation of the photostability of quantum dots.
TL;DR: It is found that even small, biologically compatible, concentrations (25 µM) of β-mercaptoethanol has a significant stabilizing effect on the emission color of QDs, but that greater amounts are required to completely abolish the spectral blue shifting or to minimize the emission intermittency of QD.
Journal ArticleDOI
Potential Use of Quantum Dots in Flow Cytometry
Raquel Ibáñez-Peral,Peter L. Bergquist,Malcolm R. Walter,Moreland D. Gibbs,Ewa M. Goldys,Belinda C. Ferrari +5 more
TL;DR: Flow cytometric comparisons indicated that the minimum fluorophore concentration required for detection of QDs above autofluorescent background was 100-fold less than for FITC.
Journal ArticleDOI
Inside single cells: quantitative analysis with advanced optics and nanomaterials.
Yi Cui,Joseph Irudayaraj +1 more
TL;DR: It is the expectation that the information content and implication will outweigh the costs given the impact on life science enabled by single-cell analysis.
Journal ArticleDOI
New technology and clinical applications of nanomedicine.
TL;DR: The development of a cancer therapy monitoring/diagnostic platform device such a device is intended to provide near real time monitoring of patient blood for cancer cells, cell derived nanoparticulates, such as high molecular weight DNA fragments.
References
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Journal ArticleDOI
Semiconductor Nanocrystals as Fluorescent Biological Labels
TL;DR: Semiconductor nanocrystals prepared for use as fluorescent probes in biological staining and diagnostics have a narrow, tunable, symmetric emission spectrum and are photochemically stable.
Journal ArticleDOI
Quantum Dot Bioconjugates for Ultrasensitive Nonisotopic Detection
Warren C. W. Chan,Shuming Nie +1 more
TL;DR: Highly luminescent semiconductor quantum dots (zinc sulfide-capped cadmium selenide) have been covalently coupled to biomolecules for use in ultrasensitive biological detection and these nanometer-sized conjugates are water-soluble and biocompatible.
Journal Article
Long-Circulating and Target-Specific Nanoparticles: Theory to Practice
TL;DR: The surface mechanisms, which affords red blood cells long-circulatory lives and the ability of specific microorganisms to evade macrophage recognition, are explored and the rational approaches in the design as well as the biological performance of such constructs are assessed.
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Nanoparticles in cancer therapy and diagnosis
TL;DR: The in vivo fate of these systems, after intravascular or tumoral administration, is discussed, as well as the mechanism involved in tumor regression, and the application of nanoparticles in imaging for cancer diagnosis is focused on.
Journal ArticleDOI
Effect of pegylation on pharmaceuticals
J. Milton Harris,Robert B. Chess +1 more
TL;DR: How PEGylation can result in drugs that are often more effective and safer, and which show improved patient convenience and compliance are reviewed.