Journal ArticleDOI
Noninvasive Imaging of Quantum Dots in Mice
TLDR
Long-term experiments demonstrated that these quantum dots remain fluorescent after at least four months in vivo, using only quantum dots for detection.About:
This article is published in Bioconjugate Chemistry.The article was published on 2004-01-01. It has received 1153 citations till now. The article focuses on the topics: Quantum dot & Fluorescence-lifetime imaging microscopy.read more
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Quantum dots for biomedical applications.
TL;DR: The most promising uses of quantum dots for translational research are reviewed, ranging from multiplexed immunofluorescence, targeted drug delivery coupled with disease visualization, tumor and sentinel organs localization and long-term cell tracing.
Journal ArticleDOI
Quantum Dots for Molecular Diagnostics of Tumors
TL;DR: The prospects of QD application for molecular diagnostics of tumors ranging from cancer-specific marker detection on microplates to non-invasive tumor imaging in vivo are discussed.
Journal ArticleDOI
Imaging characteristics of zinc sulfide shell, cadmium telluride core quantum dots.
Hamid Daneshvar,Jennifer Nelms,Osman Muhammad,Heather M. Jackson,Jean A. Tkach,William J. Davros,Todd E. Peterson,Michael A. Vogelbaum,Marcel P. Bruchez,Steven A. Toms +9 more
TL;DR: Computed tomography studies suggest that current formulations of quantum dots might be imaged in vivo in animals, and quantum dots have the potential to function as multimodal imaging platforms in vivo.
Journal ArticleDOI
Fluorescent Properties of a Hybrid Cadmium Sulfide-Dendrimer Nanocomposite and its Quenching with Nitromethane
TL;DR: PARAFAC analysis of the excitation emission matrices (EEM) acquired as function of the nitromethane concentration showed a trilinear data structure with only one linearly independent component describing the quenching which allows robust estimation of theexcitation and emission spectra and of the quENching profiles.
Journal ArticleDOI
Metallomics insights for in vivo studies of metal based nanomaterials
TL;DR: This review aims to provide a "metallomics" (an integrated metal-assisted function bioscience) insight into the in vivo behavior and biological effects of NMs, particularly for metal-based nanomaterials (MNMs) and is based mainly on the own research and other previous works.
References
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Journal ArticleDOI
Semiconductor Nanocrystals as Fluorescent Biological Labels
TL;DR: Semiconductor nanocrystals prepared for use as fluorescent probes in biological staining and diagnostics have a narrow, tunable, symmetric emission spectrum and are photochemically stable.
Journal ArticleDOI
Quantum Dot Bioconjugates for Ultrasensitive Nonisotopic Detection
Warren C. W. Chan,Shuming Nie +1 more
TL;DR: Highly luminescent semiconductor quantum dots (zinc sulfide-capped cadmium selenide) have been covalently coupled to biomolecules for use in ultrasensitive biological detection and these nanometer-sized conjugates are water-soluble and biocompatible.
Journal Article
Long-Circulating and Target-Specific Nanoparticles: Theory to Practice
TL;DR: The surface mechanisms, which affords red blood cells long-circulatory lives and the ability of specific microorganisms to evade macrophage recognition, are explored and the rational approaches in the design as well as the biological performance of such constructs are assessed.
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Nanoparticles in cancer therapy and diagnosis
TL;DR: The in vivo fate of these systems, after intravascular or tumoral administration, is discussed, as well as the mechanism involved in tumor regression, and the application of nanoparticles in imaging for cancer diagnosis is focused on.
Journal ArticleDOI
Effect of pegylation on pharmaceuticals
J. Milton Harris,Robert B. Chess +1 more
TL;DR: How PEGylation can result in drugs that are often more effective and safer, and which show improved patient convenience and compliance are reviewed.