Journal ArticleDOI
Noninvasive Imaging of Quantum Dots in Mice
TLDR
Long-term experiments demonstrated that these quantum dots remain fluorescent after at least four months in vivo, using only quantum dots for detection.About:
This article is published in Bioconjugate Chemistry.The article was published on 2004-01-01. It has received 1153 citations till now. The article focuses on the topics: Quantum dot & Fluorescence-lifetime imaging microscopy.read more
Citations
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Oxidative quenching and degradation of polymer-encapsulated quantum dots: new insights into the long-term fate and toxicity of nanocrystals in vivo.
TL;DR: It is found that significant fluorescence quenching occurs before QD dissolution and that localized surface defects can be repaired or "annealed" by UV light illumination, which have important implications regarding the long-term fate and potential toxicity of semiconductor nanocrystals in vivo.
Journal ArticleDOI
Quantum dot nanocrystals for in vivo molecular and cellular imaging
TL;DR: Semiconductor quantum dots (QD) are nanometer-sized crystals with unique photochemical and photophysical properties that are not available from either isolated molecules or bulk solids.
Journal ArticleDOI
Acute toxicity and prothrombotic effects of quantum dots: impact of surface charge.
Jorina Geys,Abderrahim Nemmar,Erik Verbeken,Erik Smolders,Monica Ratoi,Marc Hoylaerts,Benoit Nemery,Peter Hoet +7 more
TL;DR: At high doses, QDs caused pulmonary vascular thrombosis, most likely by activating the coagulation cascade via contact activation, and it is clear that surface charge is an important parameter in nanotoxicity.
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From diagnostics to therapy: prospects of quantum dots.
TL;DR: Quantum dots (QDs) appear to be too valuable to nanomedicine to dismiss, and will eventually come into routine practical use.
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Tumour-on-a-chip provides an optical window into nanoparticle tissue transport
Alexandre Albanese,Alan K. Lam,Alan K. Lam,Edward A. Sykes,Jonathan V. Rocheleau,Jonathan V. Rocheleau,Warren C. W. Chan +6 more
TL;DR: It is shown that penetration of nanoparticles into the tissue is limited by their diameter and retention can be improved by receptor-targeting, and that the tumour-on-a-chip can be useful for screening optimal nanoparticle designs prior to in vivo studies.
References
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Journal ArticleDOI
Semiconductor Nanocrystals as Fluorescent Biological Labels
TL;DR: Semiconductor nanocrystals prepared for use as fluorescent probes in biological staining and diagnostics have a narrow, tunable, symmetric emission spectrum and are photochemically stable.
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Quantum Dot Bioconjugates for Ultrasensitive Nonisotopic Detection
Warren C. W. Chan,Shuming Nie +1 more
TL;DR: Highly luminescent semiconductor quantum dots (zinc sulfide-capped cadmium selenide) have been covalently coupled to biomolecules for use in ultrasensitive biological detection and these nanometer-sized conjugates are water-soluble and biocompatible.
Journal Article
Long-Circulating and Target-Specific Nanoparticles: Theory to Practice
TL;DR: The surface mechanisms, which affords red blood cells long-circulatory lives and the ability of specific microorganisms to evade macrophage recognition, are explored and the rational approaches in the design as well as the biological performance of such constructs are assessed.
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Nanoparticles in cancer therapy and diagnosis
TL;DR: The in vivo fate of these systems, after intravascular or tumoral administration, is discussed, as well as the mechanism involved in tumor regression, and the application of nanoparticles in imaging for cancer diagnosis is focused on.
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Effect of pegylation on pharmaceuticals
J. Milton Harris,Robert B. Chess +1 more
TL;DR: How PEGylation can result in drugs that are often more effective and safer, and which show improved patient convenience and compliance are reviewed.