Journal ArticleDOI
Noninvasive Imaging of Quantum Dots in Mice
TLDR
Long-term experiments demonstrated that these quantum dots remain fluorescent after at least four months in vivo, using only quantum dots for detection.About:
This article is published in Bioconjugate Chemistry.The article was published on 2004-01-01. It has received 1153 citations till now. The article focuses on the topics: Quantum dot & Fluorescence-lifetime imaging microscopy.read more
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Application of quantum dots-based biotechnology in cancer diagnosis: current status and future perspectives
Chun-Wei Peng,Yan Li +1 more
TL;DR: In this paper, the authors focus on recent application of QDs in cancer diagnosis and treatment, including early detection of primary tumor such as ovarian cancer, breast cancer, prostate cancer and pancreatic cancer, as well as regional lymph nodes and distant metastases.
Journal ArticleDOI
Quantum Dot as a Drug Tracer In Vivo
TL;DR: This work conjugated QDs with captopril, anti-hypertensive medicine, by an exchange reaction while retaining the medicinal properties and succeeded in analyzing the dynamics and kinetics of small molecules using fluorescence of QDs.
Journal ArticleDOI
Be Active or Not: the Relative Contribution of Active and Passive Tumor Targeting of Nanomaterials.
TL;DR: It is demonstrated that contribution of the active and passive effects to total accumulation of NMs in tumors varies with time, and that the receptor-mediated targeting contributes more than the EPR effect over time.
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Bioapplication of nanosemiconductors
TL;DR: In this paper, the authors introduce some of the latest examples of semiconducting nanostructures that have been applied successfully to problems in biotechnology, with a special focus on biosensing and bioimaging.
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The chemical fate of the Cd/Se/Te-based quantum dot 705 in the biological system: toxicity implications.
Chia-Hua Lin,Louis W. Chang,Han Chang,Mo-Hsiung Yang,Chung-Shi Yang,Wan-Hau Lai,Wan-Hsuan Chang,Pinpin Lin +7 more
TL;DR: It is demonstrated that free Cd indeed can be released from QD705 in the kidneys and increases the risk of renal toxicity and is not as stable or biologically inert as many may have once believed.
References
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Journal ArticleDOI
Semiconductor Nanocrystals as Fluorescent Biological Labels
TL;DR: Semiconductor nanocrystals prepared for use as fluorescent probes in biological staining and diagnostics have a narrow, tunable, symmetric emission spectrum and are photochemically stable.
Journal ArticleDOI
Quantum Dot Bioconjugates for Ultrasensitive Nonisotopic Detection
Warren C. W. Chan,Shuming Nie +1 more
TL;DR: Highly luminescent semiconductor quantum dots (zinc sulfide-capped cadmium selenide) have been covalently coupled to biomolecules for use in ultrasensitive biological detection and these nanometer-sized conjugates are water-soluble and biocompatible.
Journal Article
Long-Circulating and Target-Specific Nanoparticles: Theory to Practice
TL;DR: The surface mechanisms, which affords red blood cells long-circulatory lives and the ability of specific microorganisms to evade macrophage recognition, are explored and the rational approaches in the design as well as the biological performance of such constructs are assessed.
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Nanoparticles in cancer therapy and diagnosis
TL;DR: The in vivo fate of these systems, after intravascular or tumoral administration, is discussed, as well as the mechanism involved in tumor regression, and the application of nanoparticles in imaging for cancer diagnosis is focused on.
Journal ArticleDOI
Effect of pegylation on pharmaceuticals
J. Milton Harris,Robert B. Chess +1 more
TL;DR: How PEGylation can result in drugs that are often more effective and safer, and which show improved patient convenience and compliance are reviewed.