Journal ArticleDOI
Noninvasive Imaging of Quantum Dots in Mice
TLDR
Long-term experiments demonstrated that these quantum dots remain fluorescent after at least four months in vivo, using only quantum dots for detection.About:
This article is published in Bioconjugate Chemistry.The article was published on 2004-01-01. It has received 1153 citations till now. The article focuses on the topics: Quantum dot & Fluorescence-lifetime imaging microscopy.read more
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Effect of Poly(ethylene glycol) Length on the in Vivo Behavior of Coated Quantum Dots
TL;DR: The coating of commercial ITK705-amino QDs with methoxy-terminated poly(ethylene glycol) (PEG) of different chain lengths with significant impact on their in vivo fate after tail i.v. injection was studied by fluorescence imaging.
Journal ArticleDOI
Inhalation Exposure to Carbon Nanotubes (CNT) and Carbon Nanofibers (CNF): Methodology and Dosimetry
TL;DR: The current literature on pulmonary exposure to CNT/CNF and associated effects is summarized; recommendations and conclusions are provided that address test guideline modifications for rodent inhalation studies that will improve dosimetric extrapolation modeling for hazard and risk characterization based on the analysis of exposure-dose-response relationships.
Journal ArticleDOI
Red and near infrared persistent luminescence nano-probes for bioimaging and targeting applications
TL;DR: The significant findings suggest that, Mn2+ and/or Cr3+ doped nanostructures, particularly gallogermanates, are able to give an intense red-near infrared persistent emission with a longer afterglow time for more than 2 weeks and are suitable for bio-imaging applications.
Journal ArticleDOI
Lipid−Quantum Dot Bilayer Vesicles Enhance Tumor Cell Uptake and Retention in Vitro and in Vivo
Wafa' T Al-Jamal,Khuloud T. Al-Jamal,Bowen Tian,Lara Lacerda,Paul H. H. Bomans,Peter M. Frederik,Kostas Kostarelos +6 more
TL;DR: The hybrid L-QD bilayer vesicles presented here are thought to constitute a novel delivery system that offers the potential for transport of combinatory therapeutic and diagnostic modalities to cancer cells in vitro and in vivo.
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Long-term persistence and spectral blue shifting of quantum dots in vivo.
James A. J. Fitzpatrick,Susan Andreko,Lauren A. Ernst,Alan S. Waggoner,Byron Ballou,Marcel P. Bruchez +5 more
TL;DR: Two-photon spectral microscopy was used to verify the existence of quantum dots within two-year tissues, but also revealed a range of significantly blue-shifted emission peaks with increased bandwidths.
References
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Journal ArticleDOI
Semiconductor Nanocrystals as Fluorescent Biological Labels
TL;DR: Semiconductor nanocrystals prepared for use as fluorescent probes in biological staining and diagnostics have a narrow, tunable, symmetric emission spectrum and are photochemically stable.
Journal ArticleDOI
Quantum Dot Bioconjugates for Ultrasensitive Nonisotopic Detection
Warren C. W. Chan,Shuming Nie +1 more
TL;DR: Highly luminescent semiconductor quantum dots (zinc sulfide-capped cadmium selenide) have been covalently coupled to biomolecules for use in ultrasensitive biological detection and these nanometer-sized conjugates are water-soluble and biocompatible.
Journal Article
Long-Circulating and Target-Specific Nanoparticles: Theory to Practice
TL;DR: The surface mechanisms, which affords red blood cells long-circulatory lives and the ability of specific microorganisms to evade macrophage recognition, are explored and the rational approaches in the design as well as the biological performance of such constructs are assessed.
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Nanoparticles in cancer therapy and diagnosis
TL;DR: The in vivo fate of these systems, after intravascular or tumoral administration, is discussed, as well as the mechanism involved in tumor regression, and the application of nanoparticles in imaging for cancer diagnosis is focused on.
Journal ArticleDOI
Effect of pegylation on pharmaceuticals
J. Milton Harris,Robert B. Chess +1 more
TL;DR: How PEGylation can result in drugs that are often more effective and safer, and which show improved patient convenience and compliance are reviewed.